Version history

{
  "scope": "vip-interneurons",
  "claim_text": "In neocortex the ionotropic 5-HT3 receptor is expressed selectively by VIP/CCK-coexpressing GABAergic interneurons, where it mediates fast serotonergic synaptic excitation.",
  "raw_fields": {
    "n": null,
    "doi": "10.1523/jneurosci.22-17-07389.2002",
    "year": "2002",
    "claim": "In neocortex the ionotropic 5-HT3 receptor is expressed selectively by VIP/CCK-coexpressing GABAergic interneurons, where it mediates fast serotonergic synaptic excitation.",
    "title": "5-HT3 receptors mediate serotonergic fast synaptic excitation of neocortical vasoactive intestinal peptide/cholecystokinin interneurons",
    "journal": "",
    "species": "rat",
    "cite_key": "Ferezou2002",
    "evidence": "Patch-clamp recordings + single-cell RT-PCR in rat acute neocortical slices.",
    "effect_size": "5-HT evoked rapid inward currents in 5-HT3A+ VIP/CCK cells; the 5-HT3B subunit was absent.",
    "text_access": "abstract_only",
    "_source_cluster": "cluster_13_neuromodulation",
    "replication_status": "independently_replicated",
    "_source_cluster_index": 2,
    "claim_source_sentence": "The 5-HT3A receptor subunit was expressed selectively in a subset of GABAergic interneurons coexpressing cholecystokinin (CCK) and vasoactive intestinal peptide (VIP).",
    "replication_evidence_dois": [
      "10.1523/jneurosci.1869-10.2010",
      "10.1016/j.celrep.2018.03.111"
    ],
    "effect_size_source_sentence": "The 5-HT3B subunit was never detected, indicating that 5-HT3Rs expressed by neocortical interneurons did not contain this subunit."
  },
  "section_id": "section_08",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_08_evidence_package.json",
  "effect_size": "5-HT evoked rapid inward currents in 5-HT3A+ VIP/CCK cells; the 5-HT3B subunit was absent.",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-08-in-vivo-behavior",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-1fd860b6dd41"
  ],
  "source_span": "The 5-HT3A receptor subunit was expressed selectively in a subset of GABAergic interneurons coexpressing cholecystokinin (CCK) and vasoactive intestinal peptide (VIP).",
  "study_system": null,
  "evidence_refs": [
    {
      "ref": "paper:paper-1fd860b6dd41"
    }
  ],
  "section_title": "In Vivo Function During Behavior",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Patch-clamp recordings + single-cell RT-PCR in rat acute neocortical slices.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-08-in-vivo-behavior",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_08_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}