In neocortex the ionotropic 5-HT3 receptor is expressed selectively by VIP/CCK-…

{
  "n": null,
  "doi": "10.1523/jneurosci.22-17-07389.2002",
  "year": "2002",
  "claim": "In neocortex the ionotropic 5-HT3 receptor is expressed selectively by VIP/CCK-coexpressing GABAergic interneurons, where it mediates fast serotonergic synaptic excitation.",
  "title": "5-HT3 receptors mediate serotonergic fast synaptic excitation of neocortical vasoactive intestinal peptide/cholecystokinin interneurons",
  "journal": "",
  "species": "rat",
  "cite_key": "Ferezou2002",
  "evidence": "Patch-clamp recordings + single-cell RT-PCR in rat acute neocortical slices.",
  "effect_size": "5-HT evoked rapid inward currents in 5-HT3A+ VIP/CCK cells; the 5-HT3B subunit was absent.",
  "text_access": "abstract_only",
  "_source_cluster": "cluster_13_neuromodulation",
  "replication_status": "independently_replicated",
  "_source_cluster_index": 2,
  "claim_source_sentence": "The 5-HT3A receptor subunit was expressed selectively in a subset of GABAergic interneurons coexpressing cholecystokinin (CCK) and vasoactive intestinal peptide (VIP).",
  "replication_evidence_dois": [
    "10.1523/jneurosci.1869-10.2010",
    "10.1016/j.celrep.2018.03.111"
  ],
  "effect_size_source_sentence": "The 5-HT3B subunit was never detected, indicating that 5-HT3Rs expressed by neocortical interneurons did not contain this subunit."
}

[
  "paper:paper-1fd860b6dd41"
]

[
  {
    "ref": "paper:paper-1fd860b6dd41"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}