Version history

{
  "scope": "rat neocortex; whole-cell + scRT-PCR",
  "claim_text": "In rat neocortex, 5-HT3 receptors mediate fast serotonergic EPSPs selectively in CCK/VIP-co-expressing GABAergic interneurons, providing a major route for fast neuromodulatory recruitment of VIP cells that contributes to their state-dependent firing on top of M-current/KCNQ-driven irregularity.",
  "raw_fields": {
    "n": null,
    "doi": "10.1523/jneurosci.22-17-07389.2002",
    "claim": "In rat neocortex, 5-HT3 receptors mediate fast serotonergic EPSPs selectively in CCK/VIP-co-expressing GABAergic interneurons, providing a major route for fast neuromodulatory recruitment of VIP cells that contributes to their state-dependent firing on top of M-current/KCNQ-driven irregularity.",
    "title": null,
    "cite_key": "Ferezou2002",
    "evidence": "patch-clamp + scRT-PCR + histochemistry in rat acute cortical slices",
    "effect_size": "5-HT-induced fast depolarization mediated by 5-HT3A; selective for VIP/CCK INs",
    "text_access": "abstract_only",
    "study_system": "rat neocortex; whole-cell + scRT-PCR",
    "_source_cluster": "cluster_04_intrinsic_electrophysiology",
    "replication_status": "replicated",
    "_source_cluster_index": 47,
    "claim_source_sentence": "The 5-HT3A receptor subunit was expressed selectively in a subset of GABAergic interneurons coexpressing cholecystokinin (CCK) and vasoactive intestinal peptide (VIP).",
    "replication_evidence_dois": [
      "10.1093/cercor/bhp310"
    ],
    "effect_size_source_sentence": "In 5-HT3A-expressing VIP/CCK interneurons, serotonin induced fast membrane potential depolarizations."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "effect_size": "5-HT-induced fast depolarization mediated by 5-HT3A; selective for VIP/CCK INs",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-1fd860b6dd41"
  ],
  "source_span": "The 5-HT3A receptor subunit was expressed selectively in a subset of GABAergic interneurons coexpressing cholecystokinin (CCK) and vasoactive intestinal peptide (VIP).",
  "study_system": "rat neocortex; whole-cell + scRT-PCR",
  "evidence_refs": [
    {
      "ref": "paper:paper-1fd860b6dd41"
    }
  ],
  "section_title": "Intrinsic Electrophysiology",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "patch-clamp + scRT-PCR + histochemistry in rat acute cortical slices",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}