- claim_text
In rat neocortex, 5-HT3 receptors mediate fast serotonergic EPSPs selectively in CCK/VIP-co-expressing GABAergic interneurons, providing a major route for fast neuromodulatory recruitment of VIP cells that contributes to their state-dependent firing on top of M-current/KCNQ-driven irregularity.
- raw_fields
{
"n": null,
"doi": "10.1523/jneurosci.22-17-07389.2002",
"claim": "In rat neocortex, 5-HT3 receptors mediate fast serotonergic EPSPs selectively in CCK/VIP-co-expressing GABAergic interneurons, providing a major route for fast neuromodulatory recruitment of VIP cells that contributes to their state-dependent firing on top of M-current/KCNQ-driven irregularity.",
"title": null,
"cite_key": "Ferezou2002",
"evidence": "patch-clamp + scRT-PCR + histochemistry in rat acute cortical slices",
"effect_size": "5-HT-induced fast depolarization mediated by 5-HT3A; selective for VIP/CCK INs",
"text_access": "abstract_only",
"study_system": "rat neocortex; whole-cell + scRT-PCR",
"_source_cluster": "cluster_04_intrinsic_electrophysiology",
"replication_status": "replicated",
"_source_cluster_index": 47,
"claim_source_sentence": "The 5-HT3A receptor subunit was expressed selectively in a subset of GABAergic interneurons coexpressing cholecystokinin (CCK) and vasoactive intestinal peptide (VIP).",
"replication_evidence_dois": [
"10.1093/cercor/bhp310"
],
"effect_size_source_sentence": "In 5-HT3A-expressing VIP/CCK interneurons, serotonin induced fast membrane potential depolarizations."
}- source_refs
[
"paper:paper-1fd860b6dd41"
]
- evidence_refs
[
{
"ref": "paper:paper-1fd860b6dd41"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}