In mouse V1, ocular-dominance plasticity during the critical period and in the…

In mouse V1, ocular-dominance plasticity during the critical period and in the adult depends on excitatory neurons in layer 4 rather than on L2/3, L5 or L6, and L4 plasticity proceeds with faster kinetics than plasticity in supragranular and infragranular layers.

{
  "n": 0,
  "doi": "10.1016/j.cub.2020.05.067",
  "claim": "In mouse V1, ocular-dominance plasticity during the critical period and in the adult depends on excitatory neurons in layer 4 rather than on L2/3, L5 or L6, and L4 plasticity proceeds with faster kinetics than plasticity in supragranular and infragranular layers.",
  "cite_key": "Frantz2020",
  "evidence": "Layer-specific conditional deletion of ngr1 (Nogo-66 receptor) in mouse V1 and assessment of ocular-dominance plasticity, with pharmacological dissection of L2/3 vs L5 contributions using AM-251.",
  "effect_size": "L4-specific ngr1 deletion → adult OD plasticity restored; L2/3, L5, L6 deletions → no effect.",
  "text_access": "abstract_only",
  "study_system": "Mouse V1; Cre-driver lines targeting excitatory neurons in individual layers; ngr1 conditional deletion; monocular deprivation paradigm; AM-251 layer-specific pharmacology",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "Deleting ngr1 in excitatory neurons in L4, but not in L2/3, L5, or L6, prevented closure of the critical period, and adult mice remained sensitive to brief monocular deprivation. Both juvenile wild-type mice and adult mice lacking ngr1 in L4 displayed OD plasticity that advanced more rapidly L4 than L2/3 or L5.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Deleting ngr1 in excitatory neurons in L4, but not in L2/3, L5, or L6, prevented closure of the critical period"
}

[
  "paper:paper-c4c760105083"
]

Deleting ngr1 in excitatory neurons in L4, but not in L2/3, L5, or L6, prevented closure of the critical period, and adult mice remained sensitive to brief monocular deprivation. Both juvenile wild-type mice and adult mice lacking ngr1 in L4 displayed OD plasticity that advanced more rapidly L4 than L2/3 or L5.

[
  {
    "ref": "paper:paper-c4c760105083"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}