- claim_text
In barrel cortex layer IV, inhibition mediated by fast-spiking interneurons is 10 times more powerful than excitatory connections, and a small number of FS neurons mediate thalamocortical feedforward inhibition that can powerfully shunt TC-mediated excitation
- raw_fields
{
"n": 0,
"doi": "10.1523/jneurosci.4727-04.2006",
"claim": "In barrel cortex layer IV, inhibition mediated by fast-spiking interneurons is 10 times more powerful than excitatory connections, and a small number of FS neurons mediate thalamocortical feedforward inhibition that can powerfully shunt TC-mediated excitation",
"evidence": "Paired intracellular recordings in layer IV barrels of rat thalamocortical slices measuring unitary synaptic connections",
"effect_size": "FS inhibition 10x more powerful than excitatory connections; TC EPSPs elicit reliable and precisely timed APs in FS neurons",
"text_access": "abstract_only",
"study_system": "rat barrel cortex layer IV, in vitro thalamocortical slices",
"replication_status": "independently replicated",
"claim_source_sentence": "Although inhibition from regular-spiking nonpyramidal interneurons to spiny neurons is comparable in strength to excitatory connections, inhibition mediated by fast-spiking (FS) interneurons is 10 times more powerful. A small number of FS neurons mediate thalamocortical feedforward inhibition in each spiny neuron and can powerfully shunt TC-mediated excitation.",
"replication_evidence_dois": [
"10.1016/j.neuron.2009.12.025"
],
"effect_size_source_sentence": "Inhibition mediated by fast-spiking (FS) interneurons is 10 times more powerful; TC EPSPs elicit reliable and precisely timed action potentials in FS neurons."
}- source_refs
[
"paper:paper-2f3c85a13dfa"
]
- source_span
Although inhibition from regular-spiking nonpyramidal interneurons to spiny neurons is comparable in strength to excitatory connections, inhibition mediated by fast-spiking (FS) interneurons is 10 times more powerful. A small number of FS neurons mediate thalamocortical feedforward inhibition in each spiny neuron and can powerfully shunt TC-mediated excitation.
- evidence_refs
[
{
"ref": "paper:paper-2f3c85a13dfa"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}