During working-memory decisions in a virtual navigation task, mouse posterior p…

During working-memory decisions in a virtual navigation task, mouse posterior parietal cortex neurons fire as choice-specific sequences spanning the trial — not as long-lived stable persistent states — and cells participating in distinct sequences are anatomically intermingled at sub-100-micrometre scales.

{
  "n": 0,
  "doi": "10.1038/nature10918",
  "claim": "During working-memory decisions in a virtual navigation task, mouse posterior parietal cortex neurons fire as choice-specific sequences spanning the trial — not as long-lived stable persistent states — and cells participating in distinct sequences are anatomically intermingled at sub-100-micrometre scales.",
  "cite_key": "Harvey2012",
  "evidence": "Sequence-based, not stable-attractor, dynamics described in PPC; the same dataset framing has been extended in subsequent PPC imaging studies.",
  "effect_size": "",
  "text_access": "abstract_only",
  "study_system": "mouse posterior parietal cortex (PPC); two-photon calcium imaging during virtual-navigation decision task",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Distinct sequences of neurons were triggered on trials with opposite behavioural choices and defined divergent, choice-specific trajectories through a state space of neuronal population activity.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1038/nn.4403"
  ],
  "effect_size_source_sentence": "Cells participating in the different sequences and at distinct time points in the task were anatomically intermixed over microcircuit length scales (<100 micrometres)."
}

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