- claim_text
Selective optogenetic activation of fast-spiking parvalbumin interneurons in mouse barrel cortex selectively amplifies gamma-band (40 Hz) oscillations, while activation of pyramidal cells amplifies only lower frequencies — providing causal cell-type-specific evidence for the fast-spiking-gamma hypothesis.
- raw_fields
{
"n": 0,
"doi": "10.1038/nature08002",
"claim": "Selective optogenetic activation of fast-spiking parvalbumin interneurons in mouse barrel cortex selectively amplifies gamma-band (40 Hz) oscillations, while activation of pyramidal cells amplifies only lower frequencies — providing causal cell-type-specific evidence for the fast-spiking-gamma hypothesis.",
"cite_key": "Cardin2009",
"evidence": "Cre-dependent ChR2 in PV-Cre mice; 40 Hz LFP power increased specifically with PV activation.",
"effect_size": "200 Hz",
"text_access": "fulltext",
"study_system": "PV-Cre mice with AAV-DIO-ChR2 in barrel cortex",
"source_cluster_id": "cluster_10",
"replication_status": "independently_replicated",
"claim_source_sentence": "Here we show that light-driven activation of fast-spiking interneurons at varied frequencies (8–200 Hz) selectively amplifies gamma oscillations.",
"replication_evidence_dois": [
"10.1038/nature07991"
],
"effect_size_source_sentence": "Here we show that light-driven activation of fast-spiking interneurons at varied frequencies (8–200 Hz) selectively amplifies gamma oscillations."
}- source_refs
[
"paper:3767f6c5-663b-42ad-bf68-d37f6f00b49d"
]
- evidence_refs
[
{
"ref": "paper:3767f6c5-663b-42ad-bf68-d37f6f00b49d"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}