Version history

{
  "scope": "PV-Cre mice with AAV-DIO-ChR2 in barrel cortex",
  "claim_text": "Selective optogenetic activation of fast-spiking parvalbumin interneurons in mouse barrel cortex selectively amplifies gamma-band (40 Hz) oscillations, while activation of pyramidal cells amplifies only lower frequencies — providing causal cell-type-specific evidence for the fast-spiking-gamma hypothesis.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/nature08002",
    "claim": "Selective optogenetic activation of fast-spiking parvalbumin interneurons in mouse barrel cortex selectively amplifies gamma-band (40 Hz) oscillations, while activation of pyramidal cells amplifies only lower frequencies — providing causal cell-type-specific evidence for the fast-spiking-gamma hypothesis.",
    "cite_key": "Cardin2009",
    "evidence": "Cre-dependent ChR2 in PV-Cre mice; 40 Hz LFP power increased specifically with PV activation.",
    "effect_size": "200 Hz",
    "text_access": "fulltext",
    "study_system": "PV-Cre mice with AAV-DIO-ChR2 in barrel cortex",
    "source_cluster_id": "cluster_10",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Here we show that light-driven activation of fast-spiking interneurons at varied frequencies (8–200 Hz) selectively amplifies gamma oscillations.",
    "replication_evidence_dois": [
      "10.1038/nature07991"
    ],
    "effect_size_source_sentence": "Here we show that light-driven activation of fast-spiking interneurons at varied frequencies (8–200 Hz) selectively amplifies gamma oscillations."
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json",
  "effect_size": "200 Hz",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-11",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:3767f6c5-663b-42ad-bf68-d37f6f00b49d"
  ],
  "source_span": "Here we show that light-driven activation of fast-spiking interneurons at varied frequencies (8–200 Hz) selectively amplifies gamma oscillations.",
  "study_system": "PV-Cre mice with AAV-DIO-ChR2 in barrel cortex",
  "evidence_refs": [
    {
      "ref": "paper:3767f6c5-663b-42ad-bf68-d37f6f00b49d"
    }
  ],
  "section_title": "Cell-Type-Specific Dissection of Loop Circuits (Opto/Chemo/Tracing)",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Cre-dependent ChR2 in PV-Cre mice; 40 Hz LFP power increased specifically with PV activation.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-11",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}