Version history

{
  "scope": "mouse V1 L2/3 + L5; PV-Cre, Sst-Cre, VIP-Cre x ChR2; paired/triple patch",
  "claim_text": "Cortical L2/3 and L5 PV, SST, and VIP interneurons exhibit a complementary connectivity rule: VIP cells preferentially inhibit SST cells (with weak inhibition of PV and other VIP cells), establishing a mutual-inhibition motif whose intrinsic-property differences (high-Rin, irregular/adapting VIP vs low-Rin fast-spiking PV vs accommodating SST) underlie VIP-driven disinhibition.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/nn.3446",
    "claim": "Cortical L2/3 and L5 PV, SST, and VIP interneurons exhibit a complementary connectivity rule: VIP cells preferentially inhibit SST cells (with weak inhibition of PV and other VIP cells), establishing a mutual-inhibition motif whose intrinsic-property differences (high-Rin, irregular/adapting VIP vs low-Rin fast-spiking PV vs accommodating SST) underlie VIP-driven disinhibition.",
    "title": null,
    "cite_key": "Pfeffer2013",
    "evidence": "Cre-driven ChR2 photostimulation of each population separately + paired patch in mouse cortex L2/3 and L5; quantification of inhibitory connection probability across all 6 directions",
    "effect_size": "VIP→SST inhibition dominant; VIP→PV minimal; PV→PV self-inhibition; SST broadly inhibits PV/VIP/PCs but not SST",
    "text_access": "fulltext",
    "study_system": "mouse V1 L2/3 + L5; PV-Cre, Sst-Cre, VIP-Cre x ChR2; paired/triple patch",
    "_source_cluster": "cluster_04_intrinsic_electrophysiology",
    "replication_status": "replicated",
    "_source_cluster_index": 36,
    "claim_source_sentence": "Pvalb cells preferentially inhibit one another, Sst cells avoid one another and inhibit all other types of interneurons and VIP cells preferentially inhibit Sst cells.",
    "replication_evidence_dois": [
      "10.1038/nature17187",
      "10.1038/nature12676"
    ],
    "effect_size_source_sentence": "Pvalb cells preferentially inhibit one another, Sst cells avoid one another and inhibit all other types of interneurons and VIP cells preferentially inhibit Sst cells."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "effect_size": "VIP→SST inhibition dominant; VIP→PV minimal; PV→PV self-inhibition; SST broadly inhibits PV/VIP/PCs but not SST",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-1659c2dc5d60"
  ],
  "source_span": "Pvalb cells preferentially inhibit one another, Sst cells avoid one another and inhibit all other types of interneurons and VIP cells preferentially inhibit Sst cells.",
  "study_system": "mouse V1 L2/3 + L5; PV-Cre, Sst-Cre, VIP-Cre x ChR2; paired/triple patch",
  "evidence_refs": [
    {
      "ref": "paper:paper-1659c2dc5d60"
    }
  ],
  "section_title": "Intrinsic Electrophysiology",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Cre-driven ChR2 photostimulation of each population separately + paired patch in mouse cortex L2/3 and L5; quantification of inhibitory connection probability across all 6 directions",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}