Cortical L2/3 and L5 PV, SST, and VIP interneurons exhibit a complementary conn…

Cortical L2/3 and L5 PV, SST, and VIP interneurons exhibit a complementary connectivity rule: VIP cells preferentially inhibit SST cells (with weak inhibition of PV and other VIP cells), establishing a mutual-inhibition motif whose intrinsic-property differences (high-Rin, irregular/adapting VIP vs low-Rin fast-spiking PV vs accommodating SST) underlie VIP-driven disinhibition.

{
  "n": null,
  "doi": "10.1038/nn.3446",
  "claim": "Cortical L2/3 and L5 PV, SST, and VIP interneurons exhibit a complementary connectivity rule: VIP cells preferentially inhibit SST cells (with weak inhibition of PV and other VIP cells), establishing a mutual-inhibition motif whose intrinsic-property differences (high-Rin, irregular/adapting VIP vs low-Rin fast-spiking PV vs accommodating SST) underlie VIP-driven disinhibition.",
  "title": null,
  "cite_key": "Pfeffer2013",
  "evidence": "Cre-driven ChR2 photostimulation of each population separately + paired patch in mouse cortex L2/3 and L5; quantification of inhibitory connection probability across all 6 directions",
  "effect_size": "VIP→SST inhibition dominant; VIP→PV minimal; PV→PV self-inhibition; SST broadly inhibits PV/VIP/PCs but not SST",
  "text_access": "fulltext",
  "study_system": "mouse V1 L2/3 + L5; PV-Cre, Sst-Cre, VIP-Cre x ChR2; paired/triple patch",
  "_source_cluster": "cluster_04_intrinsic_electrophysiology",
  "replication_status": "replicated",
  "_source_cluster_index": 36,
  "claim_source_sentence": "Pvalb cells preferentially inhibit one another, Sst cells avoid one another and inhibit all other types of interneurons and VIP cells preferentially inhibit Sst cells.",
  "replication_evidence_dois": [
    "10.1038/nature17187",
    "10.1038/nature12676"
  ],
  "effect_size_source_sentence": "Pvalb cells preferentially inhibit one another, Sst cells avoid one another and inhibit all other types of interneurons and VIP cells preferentially inhibit Sst cells."
}

[
  "paper:paper-1659c2dc5d60"
]

[
  {
    "ref": "paper:paper-1659c2dc5d60"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}