Nicotinic agonists selectively depolarize VIP/CCK cortical interneurons but not…

Nicotinic agonists selectively depolarize VIP/CCK cortical interneurons but not pyramidal cells, PV-fast spiking, or SST interneurons; the response persists in TTX/low-Ca2+ (postsynaptic), is blocked by DHβE/mecamylamine but not the α7-antagonist MLA, and the responsive cells co-express α4/α5/β2 nAChR subunits.

{
  "n": null,
  "doi": "10.1523/jneurosci.19-13-05228.1999",
  "claim": "Nicotinic agonists selectively depolarize VIP/CCK cortical interneurons but not pyramidal cells, PV-fast spiking, or SST interneurons; the response persists in TTX/low-Ca2+ (postsynaptic), is blocked by DHβE/mecamylamine but not the α7-antagonist MLA, and the responsive cells co-express α4/α5/β2 nAChR subunits.",
  "title": null,
  "cite_key": "Porter1999",
  "evidence": "Whole-cell recordings + single-cell RT-PCR in rat neocortical slices.",
  "effect_size": "qualitative cell-type-specific selectivity; pharmacological identity α4β2-like (lacking α7) nAChR.",
  "text_access": "abstract_only",
  "study_system": "rat neocortex slice",
  "_source_cluster": "cluster_05_synaptic_connectivity",
  "replication_status": "independently_replicated",
  "_source_cluster_index": 4,
  "claim_source_sentence": "Nicotinic receptor agonists had no effect on pyramidal neurons and on most types of interneurons, including parvalbumin-expressing fast spiking interneurons and somatostatin-expressing interneurons, but selectively excited a subpopulation of interneurons coexpressing the neuropeptides vasoactive intestinal peptide (VIP) and cholecystokinin.",
  "replication_evidence_dois": [
    "10.1038/nn.4002",
    "10.1523/jneurosci.22-17-07389.2002"
  ],
  "effect_size_source_sentence": "The responses were blocked by the nicotinic receptor antagonists dihydro-beta-erythroidine and mecamylamine and persisted in the presence of the alpha7 selective nicotinic receptor antagonist methyllycaconitine, suggesting that the involved nicotinic receptors lacked the alpha7 subunit."
}

[
  "paper:paper-5f194b747ea7"
]

Nicotinic receptor agonists had no effect on pyramidal neurons and on most types of interneurons, including parvalbumin-expressing fast spiking interneurons and somatostatin-expressing interneurons, but selectively excited a subpopulation of interneurons coexpressing the neuropeptides vasoactive intestinal peptide (VIP) and cholecystokinin.

[
  {
    "ref": "paper:paper-5f194b747ea7"
  }
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}