Version history

{
  "scope": "rat neocortex slice",
  "claim_text": "Nicotinic agonists selectively depolarize VIP/CCK cortical interneurons but not pyramidal cells, PV-fast spiking, or SST interneurons; the response persists in TTX/low-Ca2+ (postsynaptic), is blocked by DHβE/mecamylamine but not the α7-antagonist MLA, and the responsive cells co-express α4/α5/β2 nAChR subunits.",
  "raw_fields": {
    "n": null,
    "doi": "10.1523/jneurosci.19-13-05228.1999",
    "claim": "Nicotinic agonists selectively depolarize VIP/CCK cortical interneurons but not pyramidal cells, PV-fast spiking, or SST interneurons; the response persists in TTX/low-Ca2+ (postsynaptic), is blocked by DHβE/mecamylamine but not the α7-antagonist MLA, and the responsive cells co-express α4/α5/β2 nAChR subunits.",
    "title": null,
    "cite_key": "Porter1999",
    "evidence": "Whole-cell recordings + single-cell RT-PCR in rat neocortical slices.",
    "effect_size": "qualitative cell-type-specific selectivity; pharmacological identity α4β2-like (lacking α7) nAChR.",
    "text_access": "abstract_only",
    "study_system": "rat neocortex slice",
    "_source_cluster": "cluster_05_synaptic_connectivity",
    "replication_status": "independently_replicated",
    "_source_cluster_index": 4,
    "claim_source_sentence": "Nicotinic receptor agonists had no effect on pyramidal neurons and on most types of interneurons, including parvalbumin-expressing fast spiking interneurons and somatostatin-expressing interneurons, but selectively excited a subpopulation of interneurons coexpressing the neuropeptides vasoactive intestinal peptide (VIP) and cholecystokinin.",
    "replication_evidence_dois": [
      "10.1038/nn.4002",
      "10.1523/jneurosci.22-17-07389.2002"
    ],
    "effect_size_source_sentence": "The responses were blocked by the nicotinic receptor antagonists dihydro-beta-erythroidine and mecamylamine and persisted in the presence of the alpha7 selective nicotinic receptor antagonist methyllycaconitine, suggesting that the involved nicotinic receptors lacked the alpha7 subunit."
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "effect_size": "qualitative cell-type-specific selectivity; pharmacological identity α4β2-like (lacking α7) nAChR.",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-5f194b747ea7"
  ],
  "source_span": "Nicotinic receptor agonists had no effect on pyramidal neurons and on most types of interneurons, including parvalbumin-expressing fast spiking interneurons and somatostatin-expressing interneurons, but selectively excited a subpopulation of interneurons coexpressing the neuropeptides vasoactive intestinal peptide (VIP) and cholecystokinin.",
  "study_system": "rat neocortex slice",
  "evidence_refs": [
    {
      "ref": "paper:paper-5f194b747ea7"
    }
  ],
  "section_title": "Synaptic Properties and Connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Whole-cell recordings + single-cell RT-PCR in rat neocortical slices.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}