Version history

{
  "scope": "mouse VISp + ALM scRNA-seq (Smith et al 2019 elife)",
  "claim_text": "scRNA-seq of mouse VISp/ALM identifies VIP among the four most highly-expressed neuropeptide-precursor (NPP) transcripts in cortical neurons (alongside Npy, Sst, Tac2), and reveals that every neuron type expresses multiple NPPs and NP-GPCRs — implying that the VIP class participates in a dense, layered peptidergic neuromodulatory network whose volume transmission complements its fast GABAergic disinhibition output.",
  "raw_fields": {
    "n": 22439,
    "doi": "10.7554/elife.47889",
    "claim": "scRNA-seq of mouse VISp/ALM identifies VIP among the four most highly-expressed neuropeptide-precursor (NPP) transcripts in cortical neurons (alongside Npy, Sst, Tac2), and reveals that every neuron type expresses multiple NPPs and NP-GPCRs — implying that the VIP class participates in a dense, layered peptidergic neuromodulatory network whose volume transmission complements its fast GABAergic disinhibition output.",
    "title": null,
    "cite_key": "Smith2019",
    "evidence": "scRNA-seq analysis of 22,439 mouse cortical neurons; NPP/NP-GPCR transcript inventory",
    "effect_size": "VIP among top 4 NPPs by peak FPKM; 18 NPPs + 29 NP-GPCRs detected; Vipr2 expressed in 0.7% of cells (rare receptor)",
    "text_access": "fulltext",
    "study_system": "mouse VISp + ALM scRNA-seq (Smith et al 2019 elife)",
    "_source_cluster": "cluster_04_intrinsic_electrophysiology",
    "replication_status": "replicated",
    "_source_cluster_index": 61,
    "claim_source_sentence": "Of these genes, Npy, Sst, Vip and Tac2 rank as the top four overall in pFPKM values, while Cck, Penk and Crh also rank in the top ten.",
    "replication_evidence_dois": [
      "10.1038/s41586-018-0654-5"
    ],
    "effect_size_source_sentence": "Percentages of the sampled neuron population expressing a given NP-GPCR gene (at greater than 1 CPM) range from more than 72% for Adcyap1r1 down to 0.7% for Vipr2."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "effect_size": "VIP among top 4 NPPs by peak FPKM; 18 NPPs + 29 NP-GPCRs detected; Vipr2 expressed in 0.7% of cells (rare receptor)",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-pm-31710287"
  ],
  "source_span": "Of these genes, Npy, Sst, Vip and Tac2 rank as the top four overall in pFPKM values, while Cck, Penk and Crh also rank in the top ten.",
  "study_system": "mouse VISp + ALM scRNA-seq (Smith et al 2019 elife)",
  "evidence_refs": [
    {
      "ref": "paper:paper-pm-31710287"
    }
  ],
  "section_title": "Intrinsic Electrophysiology",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "scRNA-seq analysis of 22,439 mouse cortical neurons; NPP/NP-GPCR transcript inventory",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}