scRNA-seq of mouse VISp/ALM identifies VIP among the four most highly-expressed…

scRNA-seq of mouse VISp/ALM identifies VIP among the four most highly-expressed neuropeptide-precursor (NPP) transcripts in cortical neurons (alongside Npy, Sst, Tac2), and reveals that every neuron type expresses multiple NPPs and NP-GPCRs — implying that the VIP class participates in a dense, layered peptidergic neuromodulatory network whose volume transmission complements its fast GABAergic disinhibition output.

{
  "n": 22439,
  "doi": "10.7554/elife.47889",
  "claim": "scRNA-seq of mouse VISp/ALM identifies VIP among the four most highly-expressed neuropeptide-precursor (NPP) transcripts in cortical neurons (alongside Npy, Sst, Tac2), and reveals that every neuron type expresses multiple NPPs and NP-GPCRs — implying that the VIP class participates in a dense, layered peptidergic neuromodulatory network whose volume transmission complements its fast GABAergic disinhibition output.",
  "title": null,
  "cite_key": "Smith2019",
  "evidence": "scRNA-seq analysis of 22,439 mouse cortical neurons; NPP/NP-GPCR transcript inventory",
  "effect_size": "VIP among top 4 NPPs by peak FPKM; 18 NPPs + 29 NP-GPCRs detected; Vipr2 expressed in 0.7% of cells (rare receptor)",
  "text_access": "fulltext",
  "study_system": "mouse VISp + ALM scRNA-seq (Smith et al 2019 elife)",
  "_source_cluster": "cluster_04_intrinsic_electrophysiology",
  "replication_status": "replicated",
  "_source_cluster_index": 61,
  "claim_source_sentence": "Of these genes, Npy, Sst, Vip and Tac2 rank as the top four overall in pFPKM values, while Cck, Penk and Crh also rank in the top ten.",
  "replication_evidence_dois": [
    "10.1038/s41586-018-0654-5"
  ],
  "effect_size_source_sentence": "Percentages of the sampled neuron population expressing a given NP-GPCR gene (at greater than 1 CPM) range from more than 72% for Adcyap1r1 down to 0.7% for Vipr2."
}

[
  "paper:paper-pm-31710287"
]

[
  {
    "ref": "paper:paper-pm-31710287"
  }
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}