Version history

{
  "scope": "review/synthesis: Fmr1-KO mice and human FXS EEG",
  "claim_text": "In Fragile X syndrome models, dysfunctional VIP+ interneurons correlate with elevated susceptibility to irrelevant stimuli, and Fmr1-KO mice exhibit elevated broadband gamma EEG power and abnormal phase-locking to gamma-modulated acoustic stimuli, paralleling human FXS phenotypes.",
  "raw_fields": {
    "n": null,
    "doi": "10.1186/s11689-025-09634-4",
    "pmid": "41469555",
    "year": "2025",
    "claim": "In Fragile X syndrome models, dysfunctional VIP+ interneurons correlate with elevated susceptibility to irrelevant stimuli, and Fmr1-KO mice exhibit elevated broadband gamma EEG power and abnormal phase-locking to gamma-modulated acoustic stimuli, paralleling human FXS phenotypes.",
    "pmcid": "PMC12755031",
    "title": "Dysfunctional neural dynamics associated with sensory phenotypes in Fragile X syndrome: insights from mouse models.",
    "authors": "",
    "journal": "",
    "cite_key": "Goel2025",
    "evidence": "Review of Fmr1-KO mouse and human FXS EEG/MEG and circuit studies linking VIP-cell dysfunction to gamma-band abnormalities.",
    "cluster_id": "cluster_09_oscillations",
    "effect_size": "elevated broadband gamma power in Fmr1 KO awake EEG (still and movement)",
    "figure_data": [],
    "text_access": "fulltext",
    "study_system": "review/synthesis: Fmr1-KO mice and human FXS EEG",
    "cited_by_count": null,
    "_source_cluster": "cluster_09_oscillations",
    "replication_status": "independently_replicated",
    "_source_cluster_index": 14,
    "claim_source_sentence": "They found that awake and freely moving adult Fmr1 KO mice exhibited elevated broadband gamma power in resting EEGs under both still (not moving) and movement conditions compared to wild-type (WT) mice. Given the influence of VIP+ cells on circuit function and behavior, one study found a correlation between dysfunction in VIP+ cells and susceptibility to irrelevant stimuli in Fmr1 KO mice [117].",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "awake and freely moving adult Fmr1 KO mice exhibited elevated broadband gamma power in resting EEGs under both still (not moving) and movement conditions compared to wild-type (WT) mice."
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "effect_size": "elevated broadband gamma power in Fmr1 KO awake EEG (still and movement)",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "source_kind": "review_finding",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:paper-8d2e7d18746d"
  ],
  "source_span": "They found that awake and freely moving adult Fmr1 KO mice exhibited elevated broadband gamma power in resting EEGs under both still (not moving) and movement conditions compared to wild-type (WT) mice. Given the influence of VIP+ cells on circuit function and behavior, one study found a correlation between dysfunction in VIP+ cells and susceptibility to irrelevant stimuli in Fmr1 KO mice [117].",
  "study_system": "review/synthesis: Fmr1-KO mice and human FXS EEG",
  "evidence_refs": [
    {
      "ref": "paper:paper-8d2e7d18746d"
    }
  ],
  "section_title": "Oscillatory Dynamics and Temporal Coordination",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Review of Fmr1-KO mouse and human FXS EEG/MEG and circuit studies linking VIP-cell dysfunction to gamma-band abnormalities.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}