In Fragile X syndrome models, dysfunctional VIP+ interneurons correlate with el…

In Fragile X syndrome models, dysfunctional VIP+ interneurons correlate with elevated susceptibility to irrelevant stimuli, and Fmr1-KO mice exhibit elevated broadband gamma EEG power and abnormal phase-locking to gamma-modulated acoustic stimuli, paralleling human FXS phenotypes.

{
  "n": null,
  "doi": "10.1186/s11689-025-09634-4",
  "pmid": "41469555",
  "year": "2025",
  "claim": "In Fragile X syndrome models, dysfunctional VIP+ interneurons correlate with elevated susceptibility to irrelevant stimuli, and Fmr1-KO mice exhibit elevated broadband gamma EEG power and abnormal phase-locking to gamma-modulated acoustic stimuli, paralleling human FXS phenotypes.",
  "pmcid": "PMC12755031",
  "title": "Dysfunctional neural dynamics associated with sensory phenotypes in Fragile X syndrome: insights from mouse models.",
  "authors": "",
  "journal": "",
  "cite_key": "Goel2025",
  "evidence": "Review of Fmr1-KO mouse and human FXS EEG/MEG and circuit studies linking VIP-cell dysfunction to gamma-band abnormalities.",
  "cluster_id": "cluster_09_oscillations",
  "effect_size": "elevated broadband gamma power in Fmr1 KO awake EEG (still and movement)",
  "figure_data": [],
  "text_access": "fulltext",
  "study_system": "review/synthesis: Fmr1-KO mice and human FXS EEG",
  "cited_by_count": null,
  "_source_cluster": "cluster_09_oscillations",
  "replication_status": "independently_replicated",
  "_source_cluster_index": 14,
  "claim_source_sentence": "They found that awake and freely moving adult Fmr1 KO mice exhibited elevated broadband gamma power in resting EEGs under both still (not moving) and movement conditions compared to wild-type (WT) mice. Given the influence of VIP+ cells on circuit function and behavior, one study found a correlation between dysfunction in VIP+ cells and susceptibility to irrelevant stimuli in Fmr1 KO mice [117].",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "awake and freely moving adult Fmr1 KO mice exhibited elevated broadband gamma power in resting EEGs under both still (not moving) and movement conditions compared to wild-type (WT) mice."
}

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They found that awake and freely moving adult Fmr1 KO mice exhibited elevated broadband gamma power in resting EEGs under both still (not moving) and movement conditions compared to wild-type (WT) mice. Given the influence of VIP+ cells on circuit function and behavior, one study found a correlation between dysfunction in VIP+ cells and susceptibility to irrelevant stimuli in Fmr1 KO mice [117].

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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
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