Excitatory connections between L2/3 neurons in mouse V1 follow a long-tailed (h…

Excitatory connections between L2/3 neurons in mouse V1 follow a long-tailed (highly skewed) strength distribution organized by functional similarity: pairs with correlated visual responses are connected much more often and via stronger synapses than uncorrelated pairs — the structural substrate for selective recurrent E→E amplification.

{
  "n": 0,
  "doi": "10.1038/nature14182",
  "claim": "Excitatory connections between L2/3 neurons in mouse V1 follow a long-tailed (highly skewed) strength distribution organized by functional similarity: pairs with correlated visual responses are connected much more often and via stronger synapses than uncorrelated pairs — the structural substrate for selective recurrent E→E amplification.",
  "cite_key": "Cossell2015",
  "evidence": "Combined two-photon calcium imaging of visual responses and paired whole-cell recording in mouse V1 L2/3 pyramidal cells; EPSPs measured pairwise.",
  "effect_size": "EPSP amplitude distribution highly skewed: median 0.19 mV, mean 0.45 ± 0.68 mV; functional correlation predicts connection probability (p = 8.2 × 10^-something, Cochran–Armitage trend)",
  "text_access": "fulltext",
  "study_system": "Mouse V1 L2/3, in vivo two-photon imaging + ex vivo paired whole-cell recording",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "We describe a simple rule governing how the long-tailed distribution of excitatory connection strength — observed in diverse cortical areas— is organized with respect to the functional properties of cortical neurons.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.1016/j.neuron.2017.08.014",
    "10.1038/nature05079"
  ],
  "effect_size_source_sentence": "Consistent with previous reports, the distribution of excitatory postsynaptic potential (EPSP) amplitudes was highly skewed (median EPSP amplitude: 0.19 mV; mean EPSP amplitude ± s.d.: 0.45 ± 0.68 mV;)."
}

[
  "paper:paper-c4ad527c9bfb"
]

[
  {
    "ref": "paper:paper-c4ad527c9bfb"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}