Version history

{
  "scope": "Mouse V1 L2/3, in vivo two-photon imaging + ex vivo paired whole-cell recording",
  "claim_text": "Excitatory connections between L2/3 neurons in mouse V1 follow a long-tailed (highly skewed) strength distribution organized by functional similarity: pairs with correlated visual responses are connected much more often and via stronger synapses than uncorrelated pairs — the structural substrate for selective recurrent E→E amplification.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/nature14182",
    "claim": "Excitatory connections between L2/3 neurons in mouse V1 follow a long-tailed (highly skewed) strength distribution organized by functional similarity: pairs with correlated visual responses are connected much more often and via stronger synapses than uncorrelated pairs — the structural substrate for selective recurrent E→E amplification.",
    "cite_key": "Cossell2015",
    "evidence": "Combined two-photon calcium imaging of visual responses and paired whole-cell recording in mouse V1 L2/3 pyramidal cells; EPSPs measured pairwise.",
    "effect_size": "EPSP amplitude distribution highly skewed: median 0.19 mV, mean 0.45 ± 0.68 mV; functional correlation predicts connection probability (p = 8.2 × 10^-something, Cochran–Armitage trend)",
    "text_access": "fulltext",
    "study_system": "Mouse V1 L2/3, in vivo two-photon imaging + ex vivo paired whole-cell recording",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "We describe a simple rule governing how the long-tailed distribution of excitatory connection strength — observed in diverse cortical areas— is organized with respect to the functional properties of cortical neurons.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2017.08.014",
      "10.1038/nature05079"
    ],
    "effect_size_source_sentence": "Consistent with previous reports, the distribution of excitatory postsynaptic potential (EPSP) amplitudes was highly skewed (median EPSP amplitude: 0.19 mV; mean EPSP amplitude ± s.d.: 0.45 ± 0.68 mV;)."
  },
  "section_id": "section_09",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "effect_size": "EPSP amplitude distribution highly skewed: median 0.19 mV, mean 0.45 ± 0.68 mV; functional correlation predicts connection probability (p = 8.2 × 10^-something, Cochran–Armitage trend)",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "source_kind": "review_finding",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:paper-c4ad527c9bfb"
  ],
  "source_span": "We describe a simple rule governing how the long-tailed distribution of excitatory connection strength — observed in diverse cortical areas— is organized with respect to the functional properties of cortical neurons.",
  "study_system": "Mouse V1 L2/3, in vivo two-photon imaging + ex vivo paired whole-cell recording",
  "evidence_refs": [
    {
      "ref": "paper:paper-c4ad527c9bfb"
    }
  ],
  "section_title": "9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Combined two-photon calcium imaging of visual responses and paired whole-cell recording in mouse V1 L2/3 pyramidal cells; EPSPs measured pairwise.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}