Version history

{
  "scope": "adult mouse primary visual cortex (V1) layer 4 pyramidal neurons, Scnn1a-Cre/Ai9",
  "claim_text": "Mouse V1 layer 4 pyramidal-pyramidal connectivity is extremely low in adult animals (~1.0% in P55+ Scnn1a-Cre/Ai9 mice; 5.2% intra-barrel-equivalent control) and declines monotonically with age from 13.2% at P15-20 to 5.1% at P30-40 to 1.0% in adult, contrasting with the much higher excitatory connectivity reported in juvenile rodent S1 L4.",
  "raw_fields": {
    "n": 971,
    "doi": "10.1038/s41467-019-12058-z",
    "claim": "Mouse V1 layer 4 pyramidal-pyramidal connectivity is extremely low in adult animals (~1.0% in P55+ Scnn1a-Cre/Ai9 mice; 5.2% intra-barrel-equivalent control) and declines monotonically with age from 13.2% at P15-20 to 5.1% at P30-40 to 1.0% in adult, contrasting with the much higher excitatory connectivity reported in juvenile rodent S1 L4.",
    "cite_key": "Scala2019",
    "evidence": "Multi-cell paired patch-clamp recordings in V1 L4 of Scnn1a-Cre/Ai9 mice at three age windows, total >1,000 tested PYR-PYR pairs.",
    "effect_size": "≥10-fold reduction in L4 PYR-PYR connection probability from juvenile to adult (13.2% → 1.0%)",
    "text_access": "fulltext",
    "study_system": "adult mouse primary visual cortex (V1) layer 4 pyramidal neurons, Scnn1a-Cre/Ai9",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "we found that the connection probability monotonically decreased with age (Supplementary Fig.): from 13.2% in P15-20 (15/114) to 5.1% in P30-40 (8/156) to 1.0% (7/701) reported above for the P55+ mice with median age P71",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1038/s41586-020-2907-3"
    ],
    "effect_size_source_sentence": "from 13.2% in P15-20 (15/114) to 5.1% in P30-40 (8/156) to 1.0% (7/701)"
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "effect_size": "≥10-fold reduction in L4 PYR-PYR connection probability from juvenile to adult (13.2% → 1.0%)",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-07967f79209a"
  ],
  "source_span": "we found that the connection probability monotonically decreased with age (Supplementary Fig.): from 13.2% in P15-20 (15/114) to 5.1% in P30-40 (8/156) to 1.0% (7/701) reported above for the P55+ mice with median age P71",
  "study_system": "adult mouse primary visual cortex (V1) layer 4 pyramidal neurons, Scnn1a-Cre/Ai9",
  "evidence_refs": [
    {
      "ref": "paper:paper-07967f79209a"
    }
  ],
  "section_title": "7. Cell-type-specific E→E motifs in mouse — IT vs PT vs CT pyramidal projection classes; L5 thick-tufted recurrence; Patch-seq and Allen mouse-cortex taxonomy intersections; transcriptomic-type-specific connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Multi-cell paired patch-clamp recordings in V1 L4 of Scnn1a-Cre/Ai9 mice at three age windows, total >1,000 tested PYR-PYR pairs.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}