Mouse V1 layer 4 pyramidal-pyramidal connectivity is extremely low in adult ani…

Mouse V1 layer 4 pyramidal-pyramidal connectivity is extremely low in adult animals (~1.0% in P55+ Scnn1a-Cre/Ai9 mice; 5.2% intra-barrel-equivalent control) and declines monotonically with age from 13.2% at P15-20 to 5.1% at P30-40 to 1.0% in adult, contrasting with the much higher excitatory connectivity reported in juvenile rodent S1 L4.

{
  "n": 971,
  "doi": "10.1038/s41467-019-12058-z",
  "claim": "Mouse V1 layer 4 pyramidal-pyramidal connectivity is extremely low in adult animals (~1.0% in P55+ Scnn1a-Cre/Ai9 mice; 5.2% intra-barrel-equivalent control) and declines monotonically with age from 13.2% at P15-20 to 5.1% at P30-40 to 1.0% in adult, contrasting with the much higher excitatory connectivity reported in juvenile rodent S1 L4.",
  "cite_key": "Scala2019",
  "evidence": "Multi-cell paired patch-clamp recordings in V1 L4 of Scnn1a-Cre/Ai9 mice at three age windows, total >1,000 tested PYR-PYR pairs.",
  "effect_size": "≥10-fold reduction in L4 PYR-PYR connection probability from juvenile to adult (13.2% → 1.0%)",
  "text_access": "fulltext",
  "study_system": "adult mouse primary visual cortex (V1) layer 4 pyramidal neurons, Scnn1a-Cre/Ai9",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "we found that the connection probability monotonically decreased with age (Supplementary Fig.): from 13.2% in P15-20 (15/114) to 5.1% in P30-40 (8/156) to 1.0% (7/701) reported above for the P55+ mice with median age P71",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.1038/s41586-020-2907-3"
  ],
  "effect_size_source_sentence": "from 13.2% in P15-20 (15/114) to 5.1% in P30-40 (8/156) to 1.0% (7/701)"
}

[
  "paper:paper-07967f79209a"
]

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  }
]

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