- claim_text
Cadherin family adhesion molecules orchestrate cell-type-specific perisomatic inhibition, with distinct cadherin pairs differentially regulating PV-basket-cell synapses onto deep-layer vs superficial-layer pyramidal neurons in mouse cortex—evidence that the cell-type-specific inhibitory connectome is established by combinatorial cadherin codes rather than uniform connectivity rules.
- raw_fields
{
"n": null,
"doi": "10.1038/s41467-025-59635-z",
"claim": "Cadherin family adhesion molecules orchestrate cell-type-specific perisomatic inhibition, with distinct cadherin pairs differentially regulating PV-basket-cell synapses onto deep-layer vs superficial-layer pyramidal neurons in mouse cortex—evidence that the cell-type-specific inhibitory connectome is established by combinatorial cadherin codes rather than uniform connectivity rules.",
"title": null,
"cite_key": "Jezequel2025",
"evidence": "Conditional cadherin knockouts; mosaic analysis; quantification of perisomatic synapse density across pyramidal subtypes.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "mouse cortex; conditional cadherin manipulations",
"target_section": "section_05",
"_source_cluster": "cluster_01_molecular_taxonomy",
"replication_status": "replication_unknown",
"_source_cluster_index": 111,
"claim_source_sentence": "Cadherins orchestrate specific patterns of perisomatic inhibition onto distinct pyramidal cell populations.",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-e15118fdb41f"
]
- evidence_refs
[
{
"ref": "paper:paper-e15118fdb41f"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}