Version history

{
  "scope": "human postmortem neocortex; bulk + snRNA-seq; SCZ vs control",
  "claim_text": "Cross-cohort RNA-seq (n=1408 incl. 672 SCZ cases) across 3 neocortical regions reveals age-dependent reductions of PV and SST cell proportions in younger SCZ cases (<70 y) and reduced per-cell VIP and SST mRNA, providing molecular substrate for SCZ-associated alterations of cortical interneuron-driven oscillations.",
  "raw_fields": {
    "n": 1408,
    "doi": "10.1016/j.bpsgos.2025.100606",
    "pmid": "41159096",
    "year": "2026",
    "claim": "Cross-cohort RNA-seq (n=1408 incl. 672 SCZ cases) across 3 neocortical regions reveals age-dependent reductions of PV and SST cell proportions in younger SCZ cases (<70 y) and reduced per-cell VIP and SST mRNA, providing molecular substrate for SCZ-associated alterations of cortical interneuron-driven oscillations.",
    "pmcid": "PMC12556227",
    "title": "Cortical GABAergic Neuron Dysregulation in Schizophrenia Is Age Dependent.",
    "authors": "",
    "journal": "",
    "cite_key": "Kiss2026",
    "evidence": "Deconvolution of 14 bulk RNA-seq datasets benchmarked against snRNA-seq and stereology in matched donors.",
    "cluster_id": "cluster_09_oscillations",
    "effect_size": "Younger SCZ: reduced PV and SST proportions; reduced per-cell VIP and SST mRNA",
    "figure_data": [],
    "text_access": "fulltext",
    "study_system": "human postmortem neocortex; bulk + snRNA-seq; SCZ vs control",
    "cited_by_count": 2,
    "_source_cluster": "cluster_09_oscillations",
    "replication_status": "single-study",
    "_source_cluster_index": 24,
    "claim_source_sentence": "Younger SCZ cases (age < 70 years) showed reduced PVALB and SST cell proportions, while older cases showed unchanged or increased proportions compared with controls. Additionally, there was robust evidence for reduced per-cell SST and vasoactive intestinal peptide mRNA among younger cases with SCZ.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Younger SCZ cases (age < 70 years) showed reduced PVALB and SST cell proportions"
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "effect_size": "Younger SCZ: reduced PV and SST proportions; reduced per-cell VIP and SST mRNA",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "source_kind": "review_finding",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:paper-3a7b408a17b0"
  ],
  "source_span": "Younger SCZ cases (age < 70 years) showed reduced PVALB and SST cell proportions, while older cases showed unchanged or increased proportions compared with controls. Additionally, there was robust evidence for reduced per-cell SST and vasoactive intestinal peptide mRNA among younger cases with SCZ.",
  "study_system": "human postmortem neocortex; bulk + snRNA-seq; SCZ vs control",
  "evidence_refs": [
    {
      "ref": "paper:paper-3a7b408a17b0"
    }
  ],
  "section_title": "Oscillatory Dynamics and Temporal Coordination",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Deconvolution of 14 bulk RNA-seq datasets benchmarked against snRNA-seq and stereology in matched donors.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}