Cross-cohort RNA-seq (n=1408 incl. 672 SCZ cases) across 3 neocortical regions…

Cross-cohort RNA-seq (n=1408 incl. 672 SCZ cases) across 3 neocortical regions reveals age-dependent reductions of PV and SST cell proportions in younger SCZ cases (<70 y) and reduced per-cell VIP and SST mRNA, providing molecular substrate for SCZ-associated alterations of cortical interneuron-driven oscillations.

{
  "n": 1408,
  "doi": "10.1016/j.bpsgos.2025.100606",
  "pmid": "41159096",
  "year": "2026",
  "claim": "Cross-cohort RNA-seq (n=1408 incl. 672 SCZ cases) across 3 neocortical regions reveals age-dependent reductions of PV and SST cell proportions in younger SCZ cases (<70 y) and reduced per-cell VIP and SST mRNA, providing molecular substrate for SCZ-associated alterations of cortical interneuron-driven oscillations.",
  "pmcid": "PMC12556227",
  "title": "Cortical GABAergic Neuron Dysregulation in Schizophrenia Is Age Dependent.",
  "authors": "",
  "journal": "",
  "cite_key": "Kiss2026",
  "evidence": "Deconvolution of 14 bulk RNA-seq datasets benchmarked against snRNA-seq and stereology in matched donors.",
  "cluster_id": "cluster_09_oscillations",
  "effect_size": "Younger SCZ: reduced PV and SST proportions; reduced per-cell VIP and SST mRNA",
  "figure_data": [],
  "text_access": "fulltext",
  "study_system": "human postmortem neocortex; bulk + snRNA-seq; SCZ vs control",
  "cited_by_count": 2,
  "_source_cluster": "cluster_09_oscillations",
  "replication_status": "single-study",
  "_source_cluster_index": 24,
  "claim_source_sentence": "Younger SCZ cases (age < 70 years) showed reduced PVALB and SST cell proportions, while older cases showed unchanged or increased proportions compared with controls. Additionally, there was robust evidence for reduced per-cell SST and vasoactive intestinal peptide mRNA among younger cases with SCZ.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Younger SCZ cases (age < 70 years) showed reduced PVALB and SST cell proportions"
}

[
  "paper:paper-3a7b408a17b0"
]

Younger SCZ cases (age < 70 years) showed reduced PVALB and SST cell proportions, while older cases showed unchanged or increased proportions compared with controls. Additionally, there was robust evidence for reduced per-cell SST and vasoactive intestinal peptide mRNA among younger cases with SCZ.

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  "notes": [
    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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