Version history

{
  "scope": "awake mouse V1; Vip-Cre + 2P imaging",
  "claim_text": "VIP neurons in mouse V1 are predominantly low-contrast-tuned: virtually all respond only at <20% contrast to front-to-back motion (congruent with self-motion during locomotion); high-contrast gratings of all directions actively *suppress* VIP firing below baseline — a suppression rare in other Cre lines — establishing VIP firing as a feature-selective gating signal rather than a generic state amplifier.",
  "raw_fields": {
    "n": null,
    "doi": "10.7554/elife.55130",
    "claim": "VIP neurons in mouse V1 are predominantly low-contrast-tuned: virtually all respond only at <20% contrast to front-to-back motion (congruent with self-motion during locomotion); high-contrast gratings of all directions actively *suppress* VIP firing below baseline — a suppression rare in other Cre lines — establishing VIP firing as a feature-selective gating signal rather than a generic state amplifier.",
    "title": null,
    "cite_key": "Millman2020",
    "evidence": "two-photon Ca2+ imaging in awake VIP-Cre/SST-Cre/Pyr mouse V1 (Lee et al 2020 eLife)",
    "effect_size": "VIP active <20% contrast; VIP suppressed below baseline at high contrast",
    "text_access": "fulltext",
    "study_system": "awake mouse V1; Vip-Cre + 2P imaging",
    "_source_cluster": "cluster_04_intrinsic_electrophysiology",
    "replication_status": "replicated",
    "_source_cluster_index": 78,
    "claim_source_sentence": "Virtually all VIP neurons responded only at low (<20%) contrast to front-to-back motion.",
    "replication_evidence_dois": [
      "10.1038/nn.4002",
      "10.1038/nature12676"
    ],
    "effect_size_source_sentence": "High contrast gratings of all directions significantly suppressed activity in a substantial fraction of VIP neurons whereas such suppression was rare in other Cre lines."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "effect_size": "VIP active <20% contrast; VIP suppressed below baseline at high contrast",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-f2c584233c97"
  ],
  "source_span": "Virtually all VIP neurons responded only at low (<20%) contrast to front-to-back motion.",
  "study_system": "awake mouse V1; Vip-Cre + 2P imaging",
  "evidence_refs": [
    {
      "ref": "paper:paper-f2c584233c97"
    }
  ],
  "section_title": "Intrinsic Electrophysiology",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "two-photon Ca2+ imaging in awake VIP-Cre/SST-Cre/Pyr mouse V1 (Lee et al 2020 eLife)",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}