VIP neurons in mouse V1 are predominantly low-contrast-tuned: virtually all res…

VIP neurons in mouse V1 are predominantly low-contrast-tuned: virtually all respond only at <20% contrast to front-to-back motion (congruent with self-motion during locomotion); high-contrast gratings of all directions actively *suppress* VIP firing below baseline — a suppression rare in other Cre lines — establishing VIP firing as a feature-selective gating signal rather than a generic state amplifier.

{
  "n": null,
  "doi": "10.7554/elife.55130",
  "claim": "VIP neurons in mouse V1 are predominantly low-contrast-tuned: virtually all respond only at <20% contrast to front-to-back motion (congruent with self-motion during locomotion); high-contrast gratings of all directions actively *suppress* VIP firing below baseline — a suppression rare in other Cre lines — establishing VIP firing as a feature-selective gating signal rather than a generic state amplifier.",
  "title": null,
  "cite_key": "Millman2020",
  "evidence": "two-photon Ca2+ imaging in awake VIP-Cre/SST-Cre/Pyr mouse V1 (Lee et al 2020 eLife)",
  "effect_size": "VIP active <20% contrast; VIP suppressed below baseline at high contrast",
  "text_access": "fulltext",
  "study_system": "awake mouse V1; Vip-Cre + 2P imaging",
  "_source_cluster": "cluster_04_intrinsic_electrophysiology",
  "replication_status": "replicated",
  "_source_cluster_index": 78,
  "claim_source_sentence": "Virtually all VIP neurons responded only at low (<20%) contrast to front-to-back motion.",
  "replication_evidence_dois": [
    "10.1038/nn.4002",
    "10.1038/nature12676"
  ],
  "effect_size_source_sentence": "High contrast gratings of all directions significantly suppressed activity in a substantial fraction of VIP neurons whereas such suppression was rare in other Cre lines."
}

[
  "paper:paper-f2c584233c97"
]

[
  {
    "ref": "paper:paper-f2c584233c97"
  }
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}