Version history

{
  "scope": "mouse somatosensory cortex, P5–P14, in vivo Ca2+ imaging",
  "claim_text": "Longitudinal calcium imaging in unanesthetized mouse pups shows that layer I CGE-derived interneurons (co-expressing 5HT3aR and reelin) display the highest degree of spontaneous synchronous calcium activity among neonatal cortical neurons, and disrupting their synchrony impairs sensory map refinement — implicating CGE-lineage L1 interneurons in early sensory circuit assembly.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.neuron.2018.06.002",
    "claim": "Longitudinal calcium imaging in unanesthetized mouse pups shows that layer I CGE-derived interneurons (co-expressing 5HT3aR and reelin) display the highest degree of spontaneous synchronous calcium activity among neonatal cortical neurons, and disrupting their synchrony impairs sensory map refinement — implicating CGE-lineage L1 interneurons in early sensory circuit assembly.",
    "title": null,
    "cite_key": "Che2018",
    "evidence": "Abstract: in vivo two-photon calcium imaging in unanesthetized mouse pups, with chemogenetic perturbation of CGE-derived L1 interneuron synchrony.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "mouse somatosensory cortex, P5–P14, in vivo Ca2+ imaging",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "single-study",
    "_source_cluster_index": 37,
    "claim_source_sentence": "By using longitudinal calcium imaging in unanesthetized mouse pups, we show that layer I (LI) interneurons, delineated by co-expression of the 5HT3a serotonin receptor (5HT3aR) and reelin (Re), display spontaneous calcium transients with the highest degree of synchrony among cortical neurons during neonatal development.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-e5dddc233ca7"
  ],
  "source_span": "By using longitudinal calcium imaging in unanesthetized mouse pups, we show that layer I (LI) interneurons, delineated by co-expression of the 5HT3a serotonin receptor (5HT3aR) and reelin (Re), display spontaneous calcium transients with the highest degree of synchrony among cortical neurons during neonatal development.",
  "study_system": "mouse somatosensory cortex, P5–P14, in vivo Ca2+ imaging",
  "evidence_refs": [
    {
      "ref": "paper:paper-e5dddc233ca7"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Abstract: in vivo two-photon calcium imaging in unanesthetized mouse pups, with chemogenetic perturbation of CGE-derived L1 interneuron synchrony.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}