- claim_text
Longitudinal calcium imaging in unanesthetized mouse pups shows that layer I CGE-derived interneurons (co-expressing 5HT3aR and reelin) display the highest degree of spontaneous synchronous calcium activity among neonatal cortical neurons, and disrupting their synchrony impairs sensory map refinement — implicating CGE-lineage L1 interneurons in early sensory circuit assembly.
- raw_fields
{
"n": null,
"doi": "10.1016/j.neuron.2018.06.002",
"claim": "Longitudinal calcium imaging in unanesthetized mouse pups shows that layer I CGE-derived interneurons (co-expressing 5HT3aR and reelin) display the highest degree of spontaneous synchronous calcium activity among neonatal cortical neurons, and disrupting their synchrony impairs sensory map refinement — implicating CGE-lineage L1 interneurons in early sensory circuit assembly.",
"title": null,
"cite_key": "Che2018",
"evidence": "Abstract: in vivo two-photon calcium imaging in unanesthetized mouse pups, with chemogenetic perturbation of CGE-derived L1 interneuron synchrony.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "mouse somatosensory cortex, P5–P14, in vivo Ca2+ imaging",
"_source_cluster": "cluster_02_development_lineage",
"replication_status": "single-study",
"_source_cluster_index": 37,
"claim_source_sentence": "By using longitudinal calcium imaging in unanesthetized mouse pups, we show that layer I (LI) interneurons, delineated by co-expression of the 5HT3a serotonin receptor (5HT3aR) and reelin (Re), display spontaneous calcium transients with the highest degree of synchrony among cortical neurons during neonatal development.",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-e5dddc233ca7"
]
- source_span
By using longitudinal calcium imaging in unanesthetized mouse pups, we show that layer I (LI) interneurons, delineated by co-expression of the 5HT3a serotonin receptor (5HT3aR) and reelin (Re), display spontaneous calcium transients with the highest degree of synchrony among cortical neurons during neonatal development.
- evidence_refs
[
{
"ref": "paper:paper-e5dddc233ca7"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}