In mouse motor cortex layer 2/3 pyramidal neurons, motor-learning-induced new s…

{
  "n": 0,
  "doi": "10.1016/j.celrep.2022.111229",
  "claim": "In mouse motor cortex layer 2/3 pyramidal neurons, motor-learning-induced new spines are preferentially active during the learned task — not a new task — whereas pre-existing spines do not show this task-specific activation.",
  "cite_key": "Qiao2022",
  "evidence": "Two-photon structural and Ca2+ imaging of L2/3 pyramidal dendritic spines showed that new spines formed 8-24 h after motor training were preferentially co-active with somatic/dendritic activity during the learned task and increased task specificity.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "Mouse motor cortex L2/3 pyramidal neurons during forelimb reaching learning (in vivo two-photon)",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "New spines, not existing spine populations, are preferentially active when mice perform the learned task rather than a new task.",
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  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
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Two-photon structural and Ca2+ imaging of L2/3 pyramidal dendritic spines showed that new spines formed 8-24 h after motor training were preferentially co-active with somatic/dendritic activity during the learned task and increased task specificity.