Version history

{
  "scope": "S1, motor cortex; Cell reports",
  "claim_text": "[S1, motor cortex] Projections from other somatosensory cortices strongly recruit parvalbumin (PV)-positive GABAergic neurons and lead to PV neuron-mediated feedforward inhibition of pyramidal neurons in S1.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.celrep.2021.108774",
    "claim": "[S1, motor cortex] Projections from other somatosensory cortices strongly recruit parvalbumin (PV)-positive GABAergic neurons and lead to PV neuron-mediated feedforward inhibition of pyramidal neurons in S1.",
    "cite_key": "Naskar2021",
    "evidence": "Extensive hierarchical yet highly reciprocal interactions among cortical areas are fundamental for information processing. However, connectivity rules governing the specificity of such corticocortical connections, and top-down feedback projections in particular, are poorly understood. We analyze synaptic strength from functionally relevant brain areas to diverse neuronal types in the primary somatosensory cortex (S1). Long-range projections from different areas preferentially engage specific set...",
    "effect_size": "SST INs receive significantly weaker inputs from wM1 (EPSCs normalized to Pyr; PV IN, 1.10 ± 0.15, 23 cells, six mice, p = 0.3447; VIP IN, 1.75 ± 0.31, 15 cells, seven mice, p < 0.0001; nonVIP-5HT3aR IN, 1.48 ± 0.36, 8 cells, three mice, p = 0.3125; SST IN, 0.49 ± 0.13, 11 cells, four mice, p = 0.0244; Wilcoxon signed-rank test;).",
    "text_access": "fulltext",
    "study_system": "S1, motor cortex; Cell reports",
    "argument_role": "supporting",
    "replication_status": "single_study",
    "claim_source_sentence": "Projections from other somatosensory cortices strongly recruit parvalbumin (PV)-positive GABAergic neurons and lead to PV neuron-mediated feedforward inhibition of pyramidal neurons in S1.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "claim_rewritten_from_source": true,
    "effect_size_source_sentence": "SST INs receive significantly weaker inputs from wM1 (EPSCs normalized to Pyr; PV IN, 1.10 ± 0.15, 23 cells, six mice, p = 0.3447; VIP IN, 1.75 ± 0.31, 15 cells, seven mice, p < 0.0001; nonVIP-5HT3aR IN, 1.48 ± 0.36, 8 cells, three mice, p = 0.3125; SST IN, 0.49 ± 0.13, 11 cells, four mice, p = 0.0244; Wilcoxon signed-rank test;)."
  },
  "section_id": "section_09",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "effect_size": "SST INs receive significantly weaker inputs from wM1 (EPSCs normalized to Pyr; PV IN, 1.10 ± 0.15, 23 cells, six mice, p = 0.3447; VIP IN, 1.75 ± 0.31, 15 cells, seven mice, p < 0.0001; nonVIP-5HT3aR IN, 1.48 ± 0.36, 8 cells, three mice, p = 0.3125; SST IN, 0.49 ± 0.13, 11 cells, four mice, p = 0.0244; Wilcoxon signed-rank test;).",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "source_kind": "review_finding",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:paper-003795d72de8"
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  "source_span": "Projections from other somatosensory cortices strongly recruit parvalbumin (PV)-positive GABAergic neurons and lead to PV neuron-mediated feedforward inhibition of pyramidal neurons in S1.",
  "study_system": "S1, motor cortex; Cell reports",
  "evidence_refs": [
    {
      "ref": "paper:paper-003795d72de8"
    }
  ],
  "section_title": "9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation",
  "source_policy": {
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    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
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  "evidence_summary": "Extensive hierarchical yet highly reciprocal interactions among cortical areas are fundamental for information processing. However, connectivity rules governing the specificity of such corticocortical connections, and top-down feedback projections in particular, are poorly understood. We analyze synaptic strength from functionally relevant brain areas to diverse neuronal types in the primary somatosensory cortex (S1). Long-range projections from different areas preferentially engage specific set...",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}