Details
- scope
- S1, motor cortex; Cell reports
- claim_text
- [S1, motor cortex] Projections from other somatosensory cortices strongly recruit parvalbumin (PV)-positive GABAergic neurons and lead to PV neuron-mediated feedforward inhibition of pyramidal neurons in S1.
- section_id
- section_09
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json
- review_repo
- ComputationalReviewRecurrence
- section_ref
- wiki_page:computationalreviewrecurrence-09-amplification-isn
- source_kind
- review_finding
- source_path
- evidence/section_09_evidence_package.json
- source_span
- Projections from other somatosensory cortices strongly recruit parvalbumin (PV)-positive GABAergic neurons and lead to PV neuron-mediated feedforward inhibition of pyramidal neurons in S1.
- study_system
- S1, motor cortex; Cell reports
- section_title
- 9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation
- review_bundle_ref
- analysis_bundle:ab-d9c479db9be9
- replication_status
- single_study
- review_package_ref
- analysis_bundle:ab-d9c479db9be9
- source_artifact_ref
- wiki_page:computationalreviewrecurrence-09-amplification-isn
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json
- commit_sha
- 79ce062d54a924ce05953ec90aa9d26044d2b48f
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (6)
- raw_fields
{ "n": null, "doi": "10.1016/j.celrep.2021.108774", "claim": "[S1, motor cortex] Projections from other somatosensory cortices strongly recruit parvalbumin (PV)-positive GABAergic neurons and lead to PV neuron-mediated feedforward inhibition of pyramidal neurons in S1.", "cite_key": "Naskar2021", "evidence": "Extensive hierarchical yet highly reciprocal interactions among cortical areas are fundamental for information processing. However, connectivity rules governing the specificity of such corticocortical connections, and top-down feedback projections in particular, are poorly understood. We analyze synaptic strength from functionally relevant brain areas to diverse neuronal types in the primary somatosensory cortex (S1). Long-range projections from different areas preferentially engage specific set...", "effect_size": "SST INs receive significantly weaker inputs from wM1 (EPSCs normalized to Pyr; PV IN, 1.10 ± 0.15, 23 cells, six mice, p = 0.3447; VIP IN, 1.75 ± 0.31, 15 cells, seven mice, p < 0.0001; nonVIP-5HT3aR IN, 1.48 ± 0.36, 8 cells, three mice, p = 0.3125; SST IN, 0.49 ± 0.13, 11 cells, four mice, p = 0.0244; Wilcoxon signed-rank test;).", "text_access": "fulltext", "study_system": "S1, motor cortex; Cell reports", "argument_role": "supporting", "replication_status": "single_study", "claim_source_sentence": "Projections from other somatosensory cortices strongly recruit parvalbumin (PV)-positive GABAergic neurons and lead to PV neuron-mediated feedforward inhibition of pyramidal neurons in S1.", "source_provenance_status": "ok", "replication_evidence_dois": [], "claim_rewritten_from_source": true, "effect_size_source_sentence": "SST INs receive significantly weaker inputs from wM1 (EPSCs normalized to Pyr; PV IN, 1.10 ± 0.15, 23 cells, six mice, p = 0.3447; VIP IN, 1.75 ± 0.31, 15 cells, seven mice, p < 0.0001; nonVIP-5HT3aR IN, 1.48 ± 0.36, 8 cells, three mice, p = 0.3125; SST IN, 0.49 ± 0.13, 11 cells, four mice, p = 0.0244; Wilcoxon signed-rank test;)." }- effect_size
SST INs receive significantly weaker inputs from wM1 (EPSCs normalized to Pyr; PV IN, 1.10 ± 0.15, 23 cells, six mice, p = 0.3447; VIP IN, 1.75 ± 0.31, 15 cells, seven mice, p < 0.0001; nonVIP-5HT3aR IN, 1.48 ± 0.36, 8 cells, three mice, p = 0.3125; SST IN, 0.49 ± 0.13, 11 cells, four mice, p = 0.0244; Wilcoxon signed-rank test;).
- source_refs
[ "paper:paper-003795d72de8" ]
- evidence_refs
[ { "ref": "paper:paper-003795d72de8" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }- evidence_summary
Extensive hierarchical yet highly reciprocal interactions among cortical areas are fundamental for information processing. However, connectivity rules governing the specificity of such corticocortical connections, and top-down feedback projections in particular, are poorly understood. We analyze synaptic strength from functionally relevant brain areas to diverse neuronal types in the primary somatosensory cortex (S1). Long-range projections from different areas preferentially engage specific set...