Version history

{
  "scope": "Mouse cortical slices; CRACM optogenetic mapping of callosal connections.",
  "claim_text": "Channelrhodopsin-2-assisted circuit mapping (CRACM) in mouse brain slices enables sub-cellular resolution mapping of long-range callosal cortico-cortical projections, demonstrating that interhemispheric callosal axons make functional excitatory connections onto identified postsynaptic pyramidal cells in defined cortical layers.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/nn1891",
    "claim": "Channelrhodopsin-2-assisted circuit mapping (CRACM) in mouse brain slices enables sub-cellular resolution mapping of long-range callosal cortico-cortical projections, demonstrating that interhemispheric callosal axons make functional excitatory connections onto identified postsynaptic pyramidal cells in defined cortical layers.",
    "cite_key": "Petreanu2007",
    "evidence": "ChR2 viral expression + brain-slice photostimulation + whole-cell recording of identified pyramidal cells in mouse cortex.",
    "effect_size": "CRACM reliably evokes single action potentials in ChR2+ callosal axons and maps their synaptic connections onto postsynaptic neurons in identified layers.",
    "text_access": "abstract_only",
    "study_system": "Mouse cortical slices; CRACM optogenetic mapping of callosal connections.",
    "argument_role": "supporting",
    "replication_status": "replicated",
    "claim_source_sentence": "We applied this technique, ChR2-assisted circuit mapping (CRACM), to map long-range callosal projections.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.7554/eLife.100478"
    ],
    "effect_size_source_sentence": "In brain slices from ChR2-expressing mice, photostimulation of ChR2-positive axons can be transduced reliably into single action potentials."
  },
  "section_id": "section_08",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "effect_size": "CRACM reliably evokes single action potentials in ChR2+ callosal axons and maps their synaptic connections onto postsynaptic neurons in identified layers.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:987379eb-ecdd-42eb-818f-383280a8fca9"
  ],
  "source_span": "We applied this technique, ChR2-assisted circuit mapping (CRACM), to map long-range callosal projections.",
  "study_system": "Mouse cortical slices; CRACM optogenetic mapping of callosal connections.",
  "evidence_refs": [
    {
      "ref": "paper:987379eb-ecdd-42eb-818f-383280a8fca9"
    }
  ],
  "section_title": "8. Cross-areal mouse cortico-cortical excitatory connectivity — hierarchical feedforward and feedback as recurrent loops at the network level; Allen Mouse Connectivity Atlas anchored views",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "ChR2 viral expression + brain-slice photostimulation + whole-cell recording of identified pyramidal cells in mouse cortex.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}