Version history

{
  "scope": "mouse neocortex layer 1 IN slice + computational model",
  "claim_text": "A biophysical model of neocortical layer-1 VIP+ interneurons (and α7 cells) shows intrinsic resonance with theta/alpha-band input near resting potential, enabled by T-type Ca2+ channel dynamics—providing an intrinsic mechanism for cortical VIP-cell engagement at theta/alpha frequencies.",
  "raw_fields": {
    "n": null,
    "doi": "10.1523/jneurosci.1876-22.2023",
    "pmid": "36931710",
    "year": "2023",
    "claim": "A biophysical model of neocortical layer-1 VIP+ interneurons (and α7 cells) shows intrinsic resonance with theta/alpha-band input near resting potential, enabled by T-type Ca2+ channel dynamics—providing an intrinsic mechanism for cortical VIP-cell engagement at theta/alpha frequencies.",
    "pmcid": "PMC10168018",
    "title": "Mechanisms of Dominant Electrophysiological Features of Four Subtypes of Layer 1 Interneurons.",
    "authors": "",
    "journal": "",
    "cite_key": "Meng2023",
    "evidence": "Slice patch-clamp characterization of L1 IN subtypes + extended exponential integrate-and-fire computational modeling.",
    "cluster_id": "cluster_09_oscillations",
    "effect_size": "VIP and α7 cell models resonate with theta/alpha-band input only near resting potential",
    "figure_data": [],
    "text_access": "fulltext",
    "study_system": "mouse neocortex layer 1 IN slice + computational model",
    "cited_by_count": 8,
    "_source_cluster": "cluster_09_oscillations",
    "replication_status": "single-study",
    "_source_cluster_index": 18,
    "claim_source_sentence": "We further test the frequency-dependent response of the VIP cell model through a dynamic gain (DG) analysis, and find that the VIP cell model can resonate with alpha/theta band input, enabled by the dynamics of the T-type Ca2+ channel.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "The VIP model resonates with theta/alpha band input only when the average input is around the resting."
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "effect_size": "VIP and α7 cell models resonate with theta/alpha-band input only near resting potential",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "source_kind": "review_finding",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:paper-6ea5df1d31f1"
  ],
  "source_span": "We further test the frequency-dependent response of the VIP cell model through a dynamic gain (DG) analysis, and find that the VIP cell model can resonate with alpha/theta band input, enabled by the dynamics of the T-type Ca2+ channel.",
  "study_system": "mouse neocortex layer 1 IN slice + computational model",
  "evidence_refs": [
    {
      "ref": "paper:paper-6ea5df1d31f1"
    }
  ],
  "section_title": "Oscillatory Dynamics and Temporal Coordination",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Slice patch-clamp characterization of L1 IN subtypes + extended exponential integrate-and-fire computational modeling.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}