Details
- scope
- mouse neocortex layer 1 IN slice + computational model
- section_id
- section_10
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json
- effect_size
- VIP and α7 cell models resonate with theta/alpha-band input only near resting potential
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-10-oscillatory-dynamics
- source_kind
- review_finding
- source_path
- evidence/section_10_evidence_package.json
- source_span
- We further test the frequency-dependent response of the VIP cell model through a dynamic gain (DG) analysis, and find that the VIP cell model can resonate with alpha/theta band input, enabled by the dynamics of the T-type Ca2+ channel.
- study_system
- mouse neocortex layer 1 IN slice + computational model
- section_title
- Oscillatory Dynamics and Temporal Coordination
- evidence_summary
- Slice patch-clamp characterization of L1 IN subtypes + extended exponential integrate-and-fire computational modeling.
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- single-study
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-10-oscillatory-dynamics
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- claim_text
A biophysical model of neocortical layer-1 VIP+ interneurons (and α7 cells) shows intrinsic resonance with theta/alpha-band input near resting potential, enabled by T-type Ca2+ channel dynamics—providing an intrinsic mechanism for cortical VIP-cell engagement at theta/alpha frequencies.
- raw_fields
{ "n": null, "doi": "10.1523/jneurosci.1876-22.2023", "pmid": "36931710", "year": "2023", "claim": "A biophysical model of neocortical layer-1 VIP+ interneurons (and α7 cells) shows intrinsic resonance with theta/alpha-band input near resting potential, enabled by T-type Ca2+ channel dynamics—providing an intrinsic mechanism for cortical VIP-cell engagement at theta/alpha frequencies.", "pmcid": "PMC10168018", "title": "Mechanisms of Dominant Electrophysiological Features of Four Subtypes of Layer 1 Interneurons.", "authors": "", "journal": "", "cite_key": "Meng2023", "evidence": "Slice patch-clamp characterization of L1 IN subtypes + extended exponential integrate-and-fire computational modeling.", "cluster_id": "cluster_09_oscillations", "effect_size": "VIP and α7 cell models resonate with theta/alpha-band input only near resting potential", "figure_data": [], "text_access": "fulltext", "study_system": "mouse neocortex layer 1 IN slice + computational model", "cited_by_count": 8, "_source_cluster": "cluster_09_oscillations", "replication_status": "single-study", "_source_cluster_index": 18, "claim_source_sentence": "We further test the frequency-dependent response of the VIP cell model through a dynamic gain (DG) analysis, and find that the VIP cell model can resonate with alpha/theta band input, enabled by the dynamics of the T-type Ca2+ channel.", "replication_evidence_dois": [], "effect_size_source_sentence": "The VIP model resonates with theta/alpha band input only when the average input is around the resting." }- source_refs
[ "paper:paper-6ea5df1d31f1" ]
- evidence_refs
[ { "ref": "paper:paper-6ea5df1d31f1" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }