Heterozygous TCF4 loss (Tcf4+/tr Pitt-Hopkins mouse model) selectively reduces…

Heterozygous TCF4 loss (Tcf4+/tr Pitt-Hopkins mouse model) selectively reduces PV+, VIP+, cortistatin+, and ChAT+ interneurons—but spares SST+ interneurons—causing cell-type-specific E/I imbalance onto PV+ and VIP+ INs and pyramidal neurons, evidence that a single transcription factor differentially regulates discrete molecularly-defined interneuron subclasses.

{
  "n": null,
  "doi": "10.1038/s41380-023-02248-z",
  "claim": "Heterozygous TCF4 loss (Tcf4+/tr Pitt-Hopkins mouse model) selectively reduces PV+, VIP+, cortistatin+, and ChAT+ interneurons—but spares SST+ interneurons—causing cell-type-specific E/I imbalance onto PV+ and VIP+ INs and pyramidal neurons, evidence that a single transcription factor differentially regulates discrete molecularly-defined interneuron subclasses.",
  "title": null,
  "cite_key": "Chen2023b",
  "evidence": "Tcf4+/tr mouse model; CSEA + cellular deconvolution from bulk RNA-seq across 5 PTHS mouse models; IHC quantification with subtype markers; electrophysiology of E/I balance.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "Tcf4+/tr mouse model of Pitt-Hopkins; bulk RNA-seq + IHC + electrophysiology",
  "target_section": "section_03",
  "_source_cluster": "cluster_01_molecular_taxonomy",
  "replication_status": "replication_unknown",
  "_source_cluster_index": 99,
  "claim_source_sentence": "In Tcf4+/tr mice, immunohistochemical (IHC) analysis of subtype-specific IN markers and reporter mice identified reductions in PV+, vasoactive intestinal peptide (VIP+), and cortistatin (CST+) expressing INs in the cortex and cholinergic (ChAT+) INs in the striatum, with the somatostatin (SST+) IN population being spared.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

[
  "paper:paper-bcba2772b0e0"
]

In Tcf4+/tr mice, immunohistochemical (IHC) analysis of subtype-specific IN markers and reporter mice identified reductions in PV+, vasoactive intestinal peptide (VIP+), and cortistatin (CST+) expressing INs in the cortex and cholinergic (ChAT+) INs in the striatum, with the somatostatin (SST+) IN population being spared.

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