Phase-resetting modeling of mouse GPe networks shows that local inhibition slow…

Phase-resetting modeling of mouse GPe networks shows that local inhibition slows and deregularizes background pallidal firing without producing periodic patterns, but in response to a shared brief inhibitory (striatal) input, neurons separate into a synchronized transient-rebound subpopulation and a sustained-inhibition subpopulation.

{
  "n": null,
  "doi": "10.1007/s10827-022-00814-y",
  "claim": "Phase-resetting modeling of mouse GPe networks shows that local inhibition slows and deregularizes background pallidal firing without producing periodic patterns, but in response to a shared brief inhibitory (striatal) input, neurons separate into a synchronized transient-rebound subpopulation and a sustained-inhibition subpopulation.",
  "cite_key": "Olivares2022",
  "evidence": "Computational network simulation using phase-resetting model parameterized from mouse GPe slice recordings, with small-world and random connectivity.",
  "effect_size": "qualitative — input-driven dichotomization of GPe responses",
  "text_access": "abstract_only",
  "study_system": "mouse / computational model (GPe phase-resetting network)",
  "source_cluster_id": "cluster_03",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "When stimulated by a shared inhibitory input, the individual neuron responses separated into two groups: one with a short and stereotyped period of inhibition followed by a transient increase in firing probability, and the other responding with a sustained inhibition.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "In both networks, the resting activity was slowed and made more irregular by the local inhibition, but it did not show any periodic pattern."
}

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  "paper:paper-00b26fc2cdcc"
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When stimulated by a shared inhibitory input, the individual neuron responses separated into two groups: one with a short and stereotyped period of inhibition followed by a transient increase in firing probability, and the other responding with a sustained inhibition.

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