A six-layer somatosensory cortex model with PV, SST and VIP and short-term plas…

A six-layer somatosensory cortex model with PV, SST and VIP and short-term plasticity replicates layer-specific firing rates and shows the PV→SOM→VIP disinhibitory pathway substantially shapes pyramidal output when SOM is sufficiently active.

{
  "n": null,
  "id": "cluster_11_finding_06",
  "doi": "10.1093/cercor/bhae378",
  "pmid": "39344196",
  "year": "2024",
  "claim": "A six-layer somatosensory cortex model with PV, SST and VIP and short-term plasticity replicates layer-specific firing rates and shows the PV→SOM→VIP disinhibitory pathway substantially shapes pyramidal output when SOM is sufficiently active.",
  "pmcid": "PMC11439972",
  "title": "A layered microcircuit model of somatosensory cortex with three interneuron types and cell-type-specific short-term plasticity.",
  "authors": "Jiang HJ, Qi G, Duarte R, Feldmeyer D, van Albada SJ.",
  "journal": "Cerebral cortex (New York, N.Y. : 1991)",
  "cite_key": "Jiang2024b",
  "evidence": "STP added to inhibitory and disinhibitory connections; ablation of disinhibitory motif quantifies its contribution.",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "layered spiking microcircuit model of somatosensory cortex (6 layers, 4 cell types)",
  "_source_cluster": "cluster_11_computational_models",
  "replication_status": "replicated_independent",
  "_source_cluster_index": 5,
  "claim_source_sentence": "This suggests that the effect of the PV SOM VIP pathway is significant when SOM cells are adequately active.",
  "replication_evidence_dois": [
    "10.1073/pnas.2504164122",
    "10.1371/journal.pcbi.1013469",
    "10.1371/journal.pcbi.1012036",
    "10.1007/s00422-021-00894-6",
    "10.7554/elife.77594"
  ],
  "effect_size_source_sentence": null
}

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  "paper:paper-8797c32e2132"
]

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  }
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  "notes": [
    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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