Version history

{
  "scope": "adult mouse whole-brain, cortical and subcortical regions (mesoscale connectome)",
  "claim_text": "The Allen Mouse Brain Connectivity Atlas — a brain-wide cellular-resolution mesoscale connectome built from EGFP-AAV anterograde tracing across hundreds of source regions and Cre lines in mouse — provides the first whole-mouse-brain weighted directed connectivity matrix that can be queried for cell-type-specific cortico-cortical and cortico-subcortical projection patterns; a computational model of the data reveals stereotyped strength distribution and inter-hemispheric symmetry of cortical connections.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/nature13186",
    "claim": "The Allen Mouse Brain Connectivity Atlas — a brain-wide cellular-resolution mesoscale connectome built from EGFP-AAV anterograde tracing across hundreds of source regions and Cre lines in mouse — provides the first whole-mouse-brain weighted directed connectivity matrix that can be queried for cell-type-specific cortico-cortical and cortico-subcortical projection patterns; a computational model of the data reveals stereotyped strength distribution and inter-hemispheric symmetry of cortical connections.",
    "cite_key": "Oh2014",
    "evidence": "EGFP-AAV anterograde tracer injections from hundreds of source regions/Cre lines combined with serial two-photon tomography in the mouse, spatially registered to a common 3D reference and analyzed with a computational connectivity model.",
    "effect_size": "qualitative — first brain-wide cellular-resolution mouse mesoscale connectome with quantitative inter-region weights",
    "text_access": "fulltext",
    "study_system": "adult mouse whole-brain, cortical and subcortical regions (mesoscale connectome)",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "we report a brain-wide, cellular-level, mesoscale connectome for the mouse. The Allen Mouse Brain Connectivity Atlas uses enhanced green fluorescent protein (EGFP)-expressing adeno-associated viral vectors to trace axonal projections from defined regions and cell types, and high-throughput serial two-photon tomography to image the EGFP-labelled axons throughout the brain",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1038/s41586-021-03970-w"
    ],
    "effect_size_source_sentence": "brain-wide, cellular-level, mesoscale connectome for the mouse"
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "effect_size": "qualitative — first brain-wide cellular-resolution mouse mesoscale connectome with quantitative inter-region weights",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-bb5df5f7b66e"
  ],
  "source_span": "we report a brain-wide, cellular-level, mesoscale connectome for the mouse. The Allen Mouse Brain Connectivity Atlas uses enhanced green fluorescent protein (EGFP)-expressing adeno-associated viral vectors to trace axonal projections from defined regions and cell types, and high-throughput serial two-photon tomography to image the EGFP-labelled axons throughout the brain",
  "study_system": "adult mouse whole-brain, cortical and subcortical regions (mesoscale connectome)",
  "evidence_refs": [
    {
      "ref": "paper:paper-bb5df5f7b66e"
    }
  ],
  "section_title": "7. Cell-type-specific E→E motifs in mouse — IT vs PT vs CT pyramidal projection classes; L5 thick-tufted recurrence; Patch-seq and Allen mouse-cortex taxonomy intersections; transcriptomic-type-specific connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "EGFP-AAV anterograde tracer injections from hundreds of source regions/Cre lines combined with serial two-photon tomography in the mouse, spatially registered to a common 3D reference and analyzed with a computational connectivity model.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}