The Allen Mouse Brain Connectivity Atlas — a brain-wide cellular-resolution mes…

The Allen Mouse Brain Connectivity Atlas — a brain-wide cellular-resolution mesoscale connectome built from EGFP-AAV anterograde tracing across hundreds of source regions and Cre lines in mouse — provides the first whole-mouse-brain weighted directed connectivity matrix that can be queried for cell-type-specific cortico-cortical and cortico-subcortical projection patterns; a computational model of the data reveals stereotyped strength distribution and inter-hemispheric symmetry of cortical connections.

{
  "n": 0,
  "doi": "10.1038/nature13186",
  "claim": "The Allen Mouse Brain Connectivity Atlas — a brain-wide cellular-resolution mesoscale connectome built from EGFP-AAV anterograde tracing across hundreds of source regions and Cre lines in mouse — provides the first whole-mouse-brain weighted directed connectivity matrix that can be queried for cell-type-specific cortico-cortical and cortico-subcortical projection patterns; a computational model of the data reveals stereotyped strength distribution and inter-hemispheric symmetry of cortical connections.",
  "cite_key": "Oh2014",
  "evidence": "EGFP-AAV anterograde tracer injections from hundreds of source regions/Cre lines combined with serial two-photon tomography in the mouse, spatially registered to a common 3D reference and analyzed with a computational connectivity model.",
  "effect_size": "qualitative — first brain-wide cellular-resolution mouse mesoscale connectome with quantitative inter-region weights",
  "text_access": "fulltext",
  "study_system": "adult mouse whole-brain, cortical and subcortical regions (mesoscale connectome)",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "we report a brain-wide, cellular-level, mesoscale connectome for the mouse. The Allen Mouse Brain Connectivity Atlas uses enhanced green fluorescent protein (EGFP)-expressing adeno-associated viral vectors to trace axonal projections from defined regions and cell types, and high-throughput serial two-photon tomography to image the EGFP-labelled axons throughout the brain",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.1038/s41586-021-03970-w"
  ],
  "effect_size_source_sentence": "brain-wide, cellular-level, mesoscale connectome for the mouse"
}

[
  "paper:paper-bb5df5f7b66e"
]

we report a brain-wide, cellular-level, mesoscale connectome for the mouse. The Allen Mouse Brain Connectivity Atlas uses enhanced green fluorescent protein (EGFP)-expressing adeno-associated viral vectors to trace axonal projections from defined regions and cell types, and high-throughput serial two-photon tomography to image the EGFP-labelled axons throughout the brain

[
  {
    "ref": "paper:paper-bb5df5f7b66e"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}