Details
- scope
- Mouse cortex; spatially resolved axonal-collateral BARseq
- claim_text
- A 30-nt barcode pool can label ~10^18 unique sequences, far exceeding the ~10^8 neurons in the mouse brain — enabling massive multiplexing of single-neuron projection labels.
- section_id
- section_12
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_12_evidence_package.json
- effect_size
- 4^30 ≈ 10^18 unique barcodes vs ~10^8 neurons
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-12
- source_kind
- review_finding
- source_path
- evidence/section_12_evidence_package.json
- source_span
- The pool of unique barcode identifiers is effectively infinite; even a 30 nucleotide (nt)-sequence has a potential diversity of 4 30 ≈ 10 18 barcodes, far surpassing the ∼10 8 neurons in the mouse brain.
- study_system
- Mouse cortex; spatially resolved axonal-collateral BARseq
- section_title
- Whole-Brain Connectomics: Mouse, Primate, Human
- evidence_summary
- Quantifies the combinatorial advantage of barcoded projectome methods (MAPseq/BARseq) over single-cell tracer reconstructions.
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-12
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_12_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1038/s41467-024-52756-x", "claim": "A 30-nt barcode pool can label ~10^18 unique sequences, far exceeding the ~10^8 neurons in the mouse brain — enabling massive multiplexing of single-neuron projection labels.", "cite_key": "Yuan2024", "evidence": "Quantifies the combinatorial advantage of barcoded projectome methods (MAPseq/BARseq) over single-cell tracer reconstructions.", "effect_size": "4^30 ≈ 10^18 unique barcodes vs ~10^8 neurons", "text_access": "fulltext", "study_system": "Mouse cortex; spatially resolved axonal-collateral BARseq", "source_cluster_id": "cluster_11", "replication_status": "independently_replicated", "claim_source_sentence": "The pool of unique barcode identifiers is effectively infinite; even a 30 nucleotide (nt)-sequence has a potential diversity of 4 30 ≈ 10 18 barcodes, far surpassing the ∼10 8 neurons in the mouse brain.", "replication_evidence_dois": [ "10.1016/j.neuron.2016.07.036", "10.1038/s41593-021-00842-4" ], "effect_size_source_sentence": "The pool of unique barcode identifiers is effectively infinite; even a 30 nucleotide (nt)-sequence has a potential diversity of 4 30 ≈ 10 18 barcodes, far surpassing the ∼10 8 neurons in the mouse brain." }- source_refs
[ "paper:paper-986527ad59ef" ]
- evidence_refs
[ { "ref": "paper:paper-986527ad59ef" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }