Version history

{
  "scope": "Mouse cortex; spatially resolved axonal-collateral BARseq",
  "claim_text": "A 30-nt barcode pool can label ~10^18 unique sequences, far exceeding the ~10^8 neurons in the mouse brain — enabling massive multiplexing of single-neuron projection labels.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/s41467-024-52756-x",
    "claim": "A 30-nt barcode pool can label ~10^18 unique sequences, far exceeding the ~10^8 neurons in the mouse brain — enabling massive multiplexing of single-neuron projection labels.",
    "cite_key": "Yuan2024",
    "evidence": "Quantifies the combinatorial advantage of barcoded projectome methods (MAPseq/BARseq) over single-cell tracer reconstructions.",
    "effect_size": "4^30 ≈ 10^18 unique barcodes vs ~10^8 neurons",
    "text_access": "fulltext",
    "study_system": "Mouse cortex; spatially resolved axonal-collateral BARseq",
    "source_cluster_id": "cluster_11",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "The pool of unique barcode identifiers is effectively infinite; even a 30 nucleotide (nt)-sequence has a potential diversity of 4 30 ≈ 10 18 barcodes, far surpassing the ∼10 8 neurons in the mouse brain.",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2016.07.036",
      "10.1038/s41593-021-00842-4"
    ],
    "effect_size_source_sentence": "The pool of unique barcode identifiers is effectively infinite; even a 30 nucleotide (nt)-sequence has a potential diversity of 4 30 ≈ 10 18 barcodes, far surpassing the ∼10 8 neurons in the mouse brain."
  },
  "section_id": "section_12",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_12_evidence_package.json",
  "effect_size": "4^30 ≈ 10^18 unique barcodes vs ~10^8 neurons",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-12",
  "source_kind": "review_finding",
  "source_path": "evidence/section_12_evidence_package.json",
  "source_refs": [
    "paper:paper-986527ad59ef"
  ],
  "source_span": "The pool of unique barcode identifiers is effectively infinite; even a 30 nucleotide (nt)-sequence has a potential diversity of 4 30 ≈ 10 18 barcodes, far surpassing the ∼10 8 neurons in the mouse brain.",
  "study_system": "Mouse cortex; spatially resolved axonal-collateral BARseq",
  "evidence_refs": [
    {
      "ref": "paper:paper-986527ad59ef"
    }
  ],
  "section_title": "Whole-Brain Connectomics: Mouse, Primate, Human",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Quantifies the combinatorial advantage of barcoded projectome methods (MAPseq/BARseq) over single-cell tracer reconstructions.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-12",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_12_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}