Version history

{
  "scope": "Mouse somatosensory cortex; layer-1 fluorobead retrograde tracing; quantitative laminar counts of labeled neurons",
  "claim_text": "In mouse S1, neurons retrogradely labelled by fluorobeads injected 140 µm from a layer-1 application site distribute across all layers with the largest contributions from L2/3 (40%), L5a (18%), L5b (11%) and L6b (13%), while L4 (5%) and L6a (1%) contribute little — quantifying the laminar origin of local L1 input.",
  "raw_fields": {
    "n": 6,
    "doi": "10.1093/cercor/bhad371",
    "claim": "In mouse S1, neurons retrogradely labelled by fluorobeads injected 140 µm from a layer-1 application site distribute across all layers with the largest contributions from L2/3 (40%), L5a (18%), L5b (11%) and L6b (13%), while L4 (5%) and L6a (1%) contribute little — quantifying the laminar origin of local L1 input.",
    "cite_key": "Ledderose2023",
    "evidence": "Retrograde tracing with fluorobeads from layer 1 in mouse S1, quantification of laminar origins at 140 µm and at the application center.",
    "effect_size": "L2/3: 40%; L5a: 18%; L5b: 11%; L4: 5%; L6a: 1%; L6b: 13%; L1: 13%.",
    "text_access": "fulltext",
    "study_system": "Mouse somatosensory cortex; layer-1 fluorobead retrograde tracing; quantitative laminar counts of labeled neurons",
    "argument_role": "supporting",
    "replication_status": "single_study",
    "claim_source_sentence": "At 140 microns from the center of the application site, we found the highest uptake of fb in L2/3 (40% of all fb-labeled neurons in n = 6 sections from n = 6 mice) and in L5 (L5a: 18%, L5b: 11%). L4 and L6a had a smaller percentage of labeled neurons (L4: 5%, L6a: 1%), and L6b had 13% of fb-labeled neurons.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "L4 and L6a had a smaller percentage of labeled neurons (L4: 5%, L6a: 1%), and L6b had 13% of fb-labeled neurons."
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "L2/3: 40%; L5a: 18%; L5b: 11%; L4: 5%; L6a: 1%; L6b: 13%; L1: 13%.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-189d92c83cf0"
  ],
  "source_span": "At 140 microns from the center of the application site, we found the highest uptake of fb in L2/3 (40% of all fb-labeled neurons in n = 6 sections from n = 6 mice) and in L5 (L5a: 18%, L5b: 11%). L4 and L6a had a smaller percentage of labeled neurons (L4: 5%, L6a: 1%), and L6b had 13% of fb-labeled neurons.",
  "study_system": "Mouse somatosensory cortex; layer-1 fluorobead retrograde tracing; quantitative laminar counts of labeled neurons",
  "evidence_refs": [
    {
      "ref": "paper:paper-189d92c83cf0"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Retrograde tracing with fluorobeads from layer 1 in mouse S1, quantification of laminar origins at 140 µm and at the application center.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}