In mouse S1, neurons retrogradely labelled by fluorobeads injected 140 µm from…

In mouse S1, neurons retrogradely labelled by fluorobeads injected 140 µm from a layer-1 application site distribute across all layers with the largest contributions from L2/3 (40%), L5a (18%), L5b (11%) and L6b (13%), while L4 (5%) and L6a (1%) contribute little — quantifying the laminar origin of local L1 input.

{
  "n": 6,
  "doi": "10.1093/cercor/bhad371",
  "claim": "In mouse S1, neurons retrogradely labelled by fluorobeads injected 140 µm from a layer-1 application site distribute across all layers with the largest contributions from L2/3 (40%), L5a (18%), L5b (11%) and L6b (13%), while L4 (5%) and L6a (1%) contribute little — quantifying the laminar origin of local L1 input.",
  "cite_key": "Ledderose2023",
  "evidence": "Retrograde tracing with fluorobeads from layer 1 in mouse S1, quantification of laminar origins at 140 µm and at the application center.",
  "effect_size": "L2/3: 40%; L5a: 18%; L5b: 11%; L4: 5%; L6a: 1%; L6b: 13%; L1: 13%.",
  "text_access": "fulltext",
  "study_system": "Mouse somatosensory cortex; layer-1 fluorobead retrograde tracing; quantitative laminar counts of labeled neurons",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "At 140 microns from the center of the application site, we found the highest uptake of fb in L2/3 (40% of all fb-labeled neurons in n = 6 sections from n = 6 mice) and in L5 (L5a: 18%, L5b: 11%). L4 and L6a had a smaller percentage of labeled neurons (L4: 5%, L6a: 1%), and L6b had 13% of fb-labeled neurons.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "L4 and L6a had a smaller percentage of labeled neurons (L4: 5%, L6a: 1%), and L6b had 13% of fb-labeled neurons."
}

[
  "paper:paper-189d92c83cf0"
]

At 140 microns from the center of the application site, we found the highest uptake of fb in L2/3 (40% of all fb-labeled neurons in n = 6 sections from n = 6 mice) and in L5 (L5a: 18%, L5b: 11%). L4 and L6a had a smaller percentage of labeled neurons (L4: 5%, L6a: 1%), and L6b had 13% of fb-labeled neurons.

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