Version history

{
  "scope": "mouse motor cortex (M1); L5 sublayer-specific corticospinal and corticostriatal pyramidal neurons; sCRACM + paired patch",
  "claim_text": "In mouse M1, the dominant L2/3→L5 excitatory pathway is fractionated into distinct sublamina-specific sub-pathways targeting corticospinal neurons in upper L5B and corticostriatal neurons in lower L5A, with potential connectivity set by sublayer position and actual connectivity by long-range projection target.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/nn.2538",
    "claim": "In mouse M1, the dominant L2/3→L5 excitatory pathway is fractionated into distinct sublamina-specific sub-pathways targeting corticospinal neurons in upper L5B and corticostriatal neurons in lower L5A, with potential connectivity set by sublayer position and actual connectivity by long-range projection target.",
    "cite_key": "Anderson2010",
    "evidence": "Channelrhodopsin-2-assisted circuit mapping (sCRACM) and paired recordings in mouse motor cortex with retrograde labeling of projection-defined L5 subtypes.",
    "effect_size": "L2/3→L5B (corticospinal) and L2/3→L5A (corticostriatal) are sublayer- and target-selective sub-pathways.",
    "text_access": "abstract_only",
    "study_system": "mouse motor cortex (M1); L5 sublayer-specific corticospinal and corticostriatal pyramidal neurons; sCRACM + paired patch",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "We found that the main excitatory pathway in mouse motor cortex, layer 2/3-->5, is fractionated into distinct pathways targeting corticospinal and corticostriatal neurons, which are involved in motor control. However, connections were selective for neurons in certain sublayers: corticospinal neurons in upper layer 5B and corticostriatal neurons in lower 5A.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1523/JNEUROSCI.4759-11.2012"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "L2/3→L5B (corticospinal) and L2/3→L5A (corticostriatal) are sublayer- and target-selective sub-pathways.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-e4f11964cdc5"
  ],
  "source_span": "We found that the main excitatory pathway in mouse motor cortex, layer 2/3-->5, is fractionated into distinct pathways targeting corticospinal and corticostriatal neurons, which are involved in motor control. However, connections were selective for neurons in certain sublayers: corticospinal neurons in upper layer 5B and corticostriatal neurons in lower 5A.",
  "study_system": "mouse motor cortex (M1); L5 sublayer-specific corticospinal and corticostriatal pyramidal neurons; sCRACM + paired patch",
  "evidence_refs": [
    {
      "ref": "paper:paper-e4f11964cdc5"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Channelrhodopsin-2-assisted circuit mapping (sCRACM) and paired recordings in mouse motor cortex with retrograde labeling of projection-defined L5 subtypes.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}