- claim_text
In mouse M1, the dominant L2/3→L5 excitatory pathway is fractionated into distinct sublamina-specific sub-pathways targeting corticospinal neurons in upper L5B and corticostriatal neurons in lower L5A, with potential connectivity set by sublayer position and actual connectivity by long-range projection target.
- raw_fields
{
"n": 0,
"doi": "10.1038/nn.2538",
"claim": "In mouse M1, the dominant L2/3→L5 excitatory pathway is fractionated into distinct sublamina-specific sub-pathways targeting corticospinal neurons in upper L5B and corticostriatal neurons in lower L5A, with potential connectivity set by sublayer position and actual connectivity by long-range projection target.",
"cite_key": "Anderson2010",
"evidence": "Channelrhodopsin-2-assisted circuit mapping (sCRACM) and paired recordings in mouse motor cortex with retrograde labeling of projection-defined L5 subtypes.",
"effect_size": "L2/3→L5B (corticospinal) and L2/3→L5A (corticostriatal) are sublayer- and target-selective sub-pathways.",
"text_access": "abstract_only",
"study_system": "mouse motor cortex (M1); L5 sublayer-specific corticospinal and corticostriatal pyramidal neurons; sCRACM + paired patch",
"argument_role": "supporting",
"replication_status": "independently_replicated",
"claim_source_sentence": "We found that the main excitatory pathway in mouse motor cortex, layer 2/3-->5, is fractionated into distinct pathways targeting corticospinal and corticostriatal neurons, which are involved in motor control. However, connections were selective for neurons in certain sublayers: corticospinal neurons in upper layer 5B and corticostriatal neurons in lower 5A.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [
"10.1523/JNEUROSCI.4759-11.2012"
],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-e4f11964cdc5"
]
- source_span
We found that the main excitatory pathway in mouse motor cortex, layer 2/3-->5, is fractionated into distinct pathways targeting corticospinal and corticostriatal neurons, which are involved in motor control. However, connections were selective for neurons in certain sublayers: corticospinal neurons in upper layer 5B and corticostriatal neurons in lower 5A.
- evidence_refs
[
{
"ref": "paper:paper-e4f11964cdc5"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}