Version history

{
  "scope": "vip-interneurons",
  "claim_text": "Active engagement during an auditory recognition task produces cholinergic axon activation that simultaneously depolarizes PV, SST and VIP interneurons in auditory cortex; modeling shows that coincident cholinergic drive of all three subtypes — not VIP-mediated disinhibition alone — is required to reproduce context-dependent suppression of cortical activity.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/nn.4436",
    "year": "2017",
    "claim": "Active engagement during an auditory recognition task produces cholinergic axon activation that simultaneously depolarizes PV, SST and VIP interneurons in auditory cortex; modeling shows that coincident cholinergic drive of all three subtypes — not VIP-mediated disinhibition alone — is required to reproduce context-dependent suppression of cortical activity.",
    "title": "Parallel processing by cortical inhibition enables context-dependent behavior",
    "journal": "",
    "species": "mouse",
    "cite_key": "Kuchibhotla2017",
    "evidence": "Two-photon imaging of cholinergic axons + interneurons + pyramidals; whole-cell recordings; computational modeling.",
    "effect_size": "Network model only matched data when cholinergic input depolarized PV, SST and VIP simultaneously.",
    "text_access": "fulltext",
    "_source_cluster": "cluster_13_neuromodulation",
    "replication_status": "supported",
    "_source_cluster_index": 9,
    "claim_source_sentence": "Cholinergic modulation was involved in context-switching, with cholinergic axons increasing activity during behavior and directly depolarizing inhibitory cells.",
    "replication_evidence_dois": [
      "10.1126/science.aag2599",
      "10.1016/j.neuron.2022.04.031"
    ],
    "effect_size_source_sentence": "Network modeling captured these findings, but only when modulation coincidently drove all three interneuron subtypes, ruling out either inhibition or disinhibition alone as sole mechanism for active engagement."
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "effect_size": "Network model only matched data when cholinergic input depolarized PV, SST and VIP simultaneously.",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "source_kind": "review_finding",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:paper-73696115e165"
  ],
  "source_span": "Cholinergic modulation was involved in context-switching, with cholinergic axons increasing activity during behavior and directly depolarizing inhibitory cells.",
  "study_system": null,
  "evidence_refs": [
    {
      "ref": "paper:paper-73696115e165"
    }
  ],
  "section_title": "Oscillatory Dynamics and Temporal Coordination",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Two-photon imaging of cholinergic axons + interneurons + pyramidals; whole-cell recordings; computational modeling.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "supported",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}