Active engagement during an auditory recognition task produces cholinergic axon…

Active engagement during an auditory recognition task produces cholinergic axon activation that simultaneously depolarizes PV, SST and VIP interneurons in auditory cortex; modeling shows that coincident cholinergic drive of all three subtypes — not VIP-mediated disinhibition alone — is required to reproduce context-dependent suppression of cortical activity.

{
  "n": null,
  "doi": "10.1038/nn.4436",
  "year": "2017",
  "claim": "Active engagement during an auditory recognition task produces cholinergic axon activation that simultaneously depolarizes PV, SST and VIP interneurons in auditory cortex; modeling shows that coincident cholinergic drive of all three subtypes — not VIP-mediated disinhibition alone — is required to reproduce context-dependent suppression of cortical activity.",
  "title": "Parallel processing by cortical inhibition enables context-dependent behavior",
  "journal": "",
  "species": "mouse",
  "cite_key": "Kuchibhotla2017",
  "evidence": "Two-photon imaging of cholinergic axons + interneurons + pyramidals; whole-cell recordings; computational modeling.",
  "effect_size": "Network model only matched data when cholinergic input depolarized PV, SST and VIP simultaneously.",
  "text_access": "fulltext",
  "_source_cluster": "cluster_13_neuromodulation",
  "replication_status": "supported",
  "_source_cluster_index": 9,
  "claim_source_sentence": "Cholinergic modulation was involved in context-switching, with cholinergic axons increasing activity during behavior and directly depolarizing inhibitory cells.",
  "replication_evidence_dois": [
    "10.1126/science.aag2599",
    "10.1016/j.neuron.2022.04.031"
  ],
  "effect_size_source_sentence": "Network modeling captured these findings, but only when modulation coincidently drove all three interneuron subtypes, ruling out either inhibition or disinhibition alone as sole mechanism for active engagement."
}

[
  "paper:paper-73696115e165"
]

[
  {
    "ref": "paper:paper-73696115e165"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}