Version history

{
  "scope": "Mouse V1 L2/3, awake behaving; two-photon holographic optogenetics + two-photon calcium imaging",
  "claim_text": "Two-photon optogenetic activation of small ensembles in mouse V1 produces matched suppression of the surrounding network, preserving the balance of activation and suppression — direct evidence of the distributed-suppression signature predicted by strongly coupled recurrent E-I cortical networks.",
  "raw_fields": {
    "n": 12,
    "doi": "10.7554/elife.58889",
    "claim": "Two-photon optogenetic activation of small ensembles in mouse V1 produces matched suppression of the surrounding network, preserving the balance of activation and suppression — direct evidence of the distributed-suppression signature predicted by strongly coupled recurrent E-I cortical networks.",
    "cite_key": "Dalgleish2020",
    "evidence": "Two-photon holographic photoactivation of 1–200 mouse V1 L2/3 pyramidal cells during a behavioral detection task with simultaneous two-photon imaging of network responses.",
    "effect_size": "200-neuron d-prime 2.39 ± 0.86; 100-neuron d-prime 2.13 ± 0.93; matched suppression maintains spontaneous balance",
    "text_access": "fulltext",
    "study_system": "Mouse V1 L2/3, awake behaving; two-photon holographic optogenetics + two-photon calcium imaging",
    "argument_role": "supporting",
    "replication_status": "within_lab",
    "claim_source_sentence": "We also demonstrate that while detection rates increase with increasing stimulation, the surrounding network responds with matched suppression which maintains the balance of activation and suppression at a level consistent with spontaneous epochs.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2023.09.010"
    ],
    "effect_size_source_sentence": "We found that animals reliably detected 2P photostimulation of both 200 and 100 neurons consistently across time, from the first session (first 200 neuron d-prime: 2.39 ± 0.86 vs 1, p=1.70 × 10paired t-test; first 100 neuron d-prime: 2.13 ± 0.93 vs 1, p=1.4 × 10paired t-test,= 12 mice) to the last session (last 200 neuron d-prime: 2.83 ± 0.62 vs 1, p=5.95 × 10paired t-test; last 100 neuron d-prime: 2.55 ± 0.7 vs 1, p=1.00 × 10paired t-test,= 12 mice) and only showed a modest improvement over time."
  },
  "section_id": "section_09",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "effect_size": "200-neuron d-prime 2.39 ± 0.86; 100-neuron d-prime 2.13 ± 0.93; matched suppression maintains spontaneous balance",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "source_kind": "review_finding",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:paper-d2118dd5013a"
  ],
  "source_span": "We also demonstrate that while detection rates increase with increasing stimulation, the surrounding network responds with matched suppression which maintains the balance of activation and suppression at a level consistent with spontaneous epochs.",
  "study_system": "Mouse V1 L2/3, awake behaving; two-photon holographic optogenetics + two-photon calcium imaging",
  "evidence_refs": [
    {
      "ref": "paper:paper-d2118dd5013a"
    }
  ],
  "section_title": "9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Two-photon holographic photoactivation of 1–200 mouse V1 L2/3 pyramidal cells during a behavioral detection task with simultaneous two-photon imaging of network responses.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "within_lab",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}