Two-photon optogenetic activation of small ensembles in mouse V1 produces match…

Two-photon optogenetic activation of small ensembles in mouse V1 produces matched suppression of the surrounding network, preserving the balance of activation and suppression — direct evidence of the distributed-suppression signature predicted by strongly coupled recurrent E-I cortical networks.

{
  "n": 12,
  "doi": "10.7554/elife.58889",
  "claim": "Two-photon optogenetic activation of small ensembles in mouse V1 produces matched suppression of the surrounding network, preserving the balance of activation and suppression — direct evidence of the distributed-suppression signature predicted by strongly coupled recurrent E-I cortical networks.",
  "cite_key": "Dalgleish2020",
  "evidence": "Two-photon holographic photoactivation of 1–200 mouse V1 L2/3 pyramidal cells during a behavioral detection task with simultaneous two-photon imaging of network responses.",
  "effect_size": "200-neuron d-prime 2.39 ± 0.86; 100-neuron d-prime 2.13 ± 0.93; matched suppression maintains spontaneous balance",
  "text_access": "fulltext",
  "study_system": "Mouse V1 L2/3, awake behaving; two-photon holographic optogenetics + two-photon calcium imaging",
  "argument_role": "supporting",
  "replication_status": "within_lab",
  "claim_source_sentence": "We also demonstrate that while detection rates increase with increasing stimulation, the surrounding network responds with matched suppression which maintains the balance of activation and suppression at a level consistent with spontaneous epochs.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.1016/j.neuron.2023.09.010"
  ],
  "effect_size_source_sentence": "We found that animals reliably detected 2P photostimulation of both 200 and 100 neurons consistently across time, from the first session (first 200 neuron d-prime: 2.39 ± 0.86 vs 1, p=1.70 × 10paired t-test; first 100 neuron d-prime: 2.13 ± 0.93 vs 1, p=1.4 × 10paired t-test,= 12 mice) to the last session (last 200 neuron d-prime: 2.83 ± 0.62 vs 1, p=5.95 × 10paired t-test; last 100 neuron d-prime: 2.55 ± 0.7 vs 1, p=1.00 × 10paired t-test,= 12 mice) and only showed a modest improvement over time."
}

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We also demonstrate that while detection rates increase with increasing stimulation, the surrounding network responds with matched suppression which maintains the balance of activation and suppression at a level consistent with spontaneous epochs.

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