Version history

{
  "scope": "mouse auditory cortex L5 IT (CCort) and PT (CCol) pyramidal neurons",
  "claim_text": "In mouse auditory cortex, callosal projections from the contralateral hemisphere produce opposite effects on the two main L5 pyramidal output classes: they suppress firing of cortico-cortical (CCort) IT pyramidal neurons (via fast-spiking parvalbumin interneurons) while facilitating firing of cortico-collicular (CCol) PT pyramidal neurons, defining two divergent interhemispheric microcircuits within L5.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.5049-14.2015",
    "claim": "In mouse auditory cortex, callosal projections from the contralateral hemisphere produce opposite effects on the two main L5 pyramidal output classes: they suppress firing of cortico-cortical (CCort) IT pyramidal neurons (via fast-spiking parvalbumin interneurons) while facilitating firing of cortico-collicular (CCol) PT pyramidal neurons, defining two divergent interhemispheric microcircuits within L5.",
    "cite_key": "Rock2015",
    "evidence": "ChR2-assisted optogenetic activation of contralateral callosal axons with whole-cell recording of retrogradely labeled L5 CCort (IT) and CCol (PT) neurons in mouse auditory cortex slices.",
    "effect_size": "qualitative — opposite-sign callosal modulation of two L5 projection classes via FS-PV gating",
    "text_access": "abstract_only",
    "study_system": "mouse auditory cortex L5 IT (CCort) and PT (CCol) pyramidal neurons",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "callosal projections suppress the activity of CCort pyramidal neurons, but facilitate firing of CCol pyramidal neurons. This difference is mechanistically explained by callosal activation of fast-spiking parvalbumin-expressing interneurons (FS-PARV), which provide selective inhibition to CCort pyramidal neurons",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1093/cercor/bhx025"
    ],
    "effect_size_source_sentence": "callosal projections suppress the activity of CCort pyramidal neurons, but facilitate firing of CCol pyramidal neurons"
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "effect_size": "qualitative — opposite-sign callosal modulation of two L5 projection classes via FS-PV gating",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-788d7a788b07"
  ],
  "source_span": "callosal projections suppress the activity of CCort pyramidal neurons, but facilitate firing of CCol pyramidal neurons. This difference is mechanistically explained by callosal activation of fast-spiking parvalbumin-expressing interneurons (FS-PARV), which provide selective inhibition to CCort pyramidal neurons",
  "study_system": "mouse auditory cortex L5 IT (CCort) and PT (CCol) pyramidal neurons",
  "evidence_refs": [
    {
      "ref": "paper:paper-788d7a788b07"
    }
  ],
  "section_title": "7. Cell-type-specific E→E motifs in mouse — IT vs PT vs CT pyramidal projection classes; L5 thick-tufted recurrence; Patch-seq and Allen mouse-cortex taxonomy intersections; transcriptomic-type-specific connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "ChR2-assisted optogenetic activation of contralateral callosal axons with whole-cell recording of retrogradely labeled L5 CCort (IT) and CCol (PT) neurons in mouse auditory cortex slices.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}